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| 聚-L-乳酸/β-磷酸三钙复合物生物可吸收骨折内固定棒的体内降解和组织相容性 | |
| 引用本文： | 李新松,邹俊,朱国华,齐新生,浦跃朴. 聚-L-乳酸/β-磷酸三钙复合物生物可吸收骨折内固定棒的体内降解和组织相容性[J]. 生物医学工程学杂志, 2007, 24(1): 81-86 |
| 作者姓名： | 李新松 邹俊 朱国华 齐新生 浦跃朴 |
| 作者单位： | 1. 东南大学,化学化工系,生物材料和药物释放实验室,南京,210018 2. 东南大学,附属中大医院,骨科,南京,210009 3. 东南大学,公共卫生学院,南京,210009 |
| 基金项目： | 江苏省高技术研究发展计划项目;江苏省社会科学基金;江苏省南京市科学基金 |
| 摘 要： | 将β-磷酸三钙(β-TCP)与聚-L-乳酸(PLLA)复合得到PLLA/β-TCP复合材料,用注射成型方法制备出可吸收骨折内固定棒,然后通过分子量、质量变化、扫描电镜观察、弯曲强度变化和组织学方法等研究可吸收骨折内固定棒的体内降解过程。结果表明,降解初期聚乳酸的分子量有大幅度下降,重量损失滞后。随着降解的进行,可吸收棒表面逐渐粗糙,内部逐渐出现微孔和小“沟壑”,弯曲强度从初始的151MPa下降至12周的106MPa。组织学分析显示,PLLA/β-TCP复合材料具有良好的组织相容性。 |
| 关 键 词： | 聚-L-乳酸/β-磷酸三钙复合材料 可吸收棒 体内降解 骨折内固定器 组织相容性 |
| 修稿时间： | 2004-08-312005-07-08 |
In Vivo Degradation and Tissue Compatibility of Poly-L-lactide/β-Tricalcium Phosphate Composite Rods for Internal Fixation of Bone Fractures |
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| Li Xinsong,Zou Jun,Zhu Guohua,Qi Xinsheng,Pu Yuepu. In Vivo Degradation and Tissue Compatibility of Poly-L-lactide/β-Tricalcium Phosphate Composite Rods for Internal Fixation of Bone Fractures[J]. Journal of biomedical engineering, 2007, 24(1): 81-86 | |
| Authors: | Li Xinsong Zou Jun Zhu Guohua Qi Xinsheng Pu Yuepu |
| Affiliation: | 1 Biomaterials and Drug Delivery Laboratories, Department of Chemistry and Chemical Engineering, Southeast University, Nanjing 210018,China; 2 Department of Orthopeadics, The Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China; 3 School of Public Health, Southeast University, Nanjing 210009,China |
| Abstract: | Abstract Poly-l-lactide/beta-tricalcium phosphate (PLLA/betaTCP) composite was obtained by combining ground beta-TCP with PLLA, and absorbable rods were prepared by injection moulding. Degradations of the rods were investigated by scanning electron microscope (SEM), mass loss, molecular weight and bending strength changes. At the beginning of in vivo degradation of the rods, the molecular weight of PLLA decreases sharply with the less mass losses of the rods. As in vivo degradation progress, the surfaces of the rods changed roughly, while micropores and fine groove were observed in the inner part of the rods. The bending strength of composite rods decreased from 151 MPa to 106 MPa after in vivo degradation of 12 weeks. Tissue test reveal that PLLA/beta-TCP composite has good tissue compatibility compared with PLLA. |
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