| 盐酸氨溴索口腔崩解片的研制 |
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| 引用本文： | 陶宜富,钱正.盐酸氨溴索口腔崩解片的研制[J].药学与临床研究,2007,15(3):240-242. |
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| 作者姓名： | 陶宜富 钱正 |
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| 作者单位： | 南京医科大学附属南京第一医院药剂科,南京,210006 |
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| 基金项目： | 江苏省医学科技发展基金 |
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| 摘 要： | 目的:设计制备氨溴索口腔崩解片.方法:采用正交设计,根据口腔崩解片的特点选用不同辅料,考察各处方制备崩解片的溶出度和崩解时限.结果:最佳处方为:甘露醇10克,微晶纤维素 30 g,羟丙纤维素 8 g 和碳酸氢钠 1 g.结论:制备的氨溴索口腔崩解片崩解时限符合规定,口感良好,溶出速度明显优于普通片.
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| 关 键 词： | 盐酸氨溴索 口腔崩解片 崩解时限 溶出速度 研制 盐酸氨溴索 口腔崩解片 hydrochloride ambroxol tablets 普通片 溶出速度 口感 符合规定 碳酸氢钠 羟丙纤维素 微晶纤维素 甘露醇 处方制备 最佳 结果 崩解时限 溶出度 考察 辅料 |
| 文章编号： | 1673-7806（2007）03-240-03 |
| 收稿时间： | 2006/11/23 0:00:00 |
| 修稿时间： | 2006-11-23 |
Preparation of orally disintegrating tablets of ambroxol hydrochloride |
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| TAO Yi-Fu and Qian Zheng.Preparation of orally disintegrating tablets of ambroxol hydrochloride[J].Pharmacertical and Clinical Research,2007,15(3):240-242. |
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| Authors: | TAO Yi-Fu and Qian Zheng |
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| Institution: | Department of Pharmacy, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006 , China |
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| Abstract: | Objective:To design an formula of ambroxol hydrochloride orally disintegrating tablets.Method: By using orthogonal design,different formula and active ingredients according to the characteristics of orally disintegrating tablets were evaluated by the effect of disintegrating behavior and time limit observed.Results: The optimal formulation composed of mannitol 30g,cellulose microcrystallisate(MCC) 50 g,hydroxypropyl cellulose(L-HPC) 8 g and sodium bicarbonate 1 g.Conclusion: The disintegrating time of the tablets meet the qualification standard,and it have superior taste and dissolution rate compared with normal tablets. |
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| Keywords: | Ambroxol hydrochlorid Orally disintegrating tablets Disintegrating timing Dissolution rate |
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