| 免疫检查点抑制剂及其相关性结肠炎的研究进展 |
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| 引用本文： | 郑雅丹,李岭,庞智. 免疫检查点抑制剂及其相关性结肠炎的研究进展[J]. 胃肠病学, 2020, 0(1): 51-54 |
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| 作者姓名： | 郑雅丹 李岭 庞智 |
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| 作者单位： | 苏州大学附属第一医院消化内科;南京医科大学附属苏州医院（北区）消化内科 |
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| 基金项目： | 江苏省自然科学基金面上项目(BK20161232);苏州市临床重点病种诊疗技术专项(LCZX201715);南京医科大学科技发展基金(NMUB2018215)。 |
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| 摘 要： | 免疫疗法作为一种抑制肿瘤生长的新兴治疗方法,目前受到广泛关注。免疫检查点抑制剂(ICIs)通过抑制细胞毒性T淋巴细胞相关抗原4(CTLA-4)和程序性死亡受体/配体1(PD-1/PD-L1)的活性,增强T细胞识别和杀伤肿瘤细胞的能力。由于CTLA-4、PD-1/PD-L1在调节机体对自身抗原的耐受性中有至关重要的作用,因此,ICIs可能会导致机体正常耐受的缺失,从而导致免疫相关不良反应(irAEs),结肠炎为常见的irAEs之一。本文就ICIs相关结肠炎的发生率、临床表现、诊断、危险因素、发生机制、治疗研究进展作一综述。
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| 关 键 词： | 免疫检查点抑制剂 药物不良反应 腹泻 结肠炎 |
Advances in Research on Immune Checkpoint Inhibitors and Related Colitis |
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| ZHENG Yadan,LI Ling,PANG Zhi. Advances in Research on Immune Checkpoint Inhibitors and Related Colitis[J]. Chinese Journal of Gastroenterology, 2020, 0(1): 51-54 |
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| Authors: | ZHENG Yadan LI Ling PANG Zhi |
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| Affiliation: | (Department of Gastroenterology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,215006;Department of Gastroenterology,Affiliated Suzhou Hospital(North District)of Nanjing Medical University,Suzhou,Jiangsu Province) |
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| Abstract: | Immunotherapy,as a new method to inhibit tumor growth,has attracted wide attention.Immune checkpoint inhibitors(ICIs)enhance the ability of T cells to recognize and kill tumor cells by inhibiting the activity of cytotoxic T-lymphocyte associated antigen-4(CTLA-4)and programmed death/ligand 1(PD-1/PD-L1).Since immune checkpoints(CTLA-4,PD-1/PD-L1)play a crucial role in regulating the body′s tolerance to its own antigen,ICIs may cause the loss of normal tolerance of body structure and leading to immune-related adverse effects(irAEs).Colitis is one of the common irAEs.This article reviewed advances in research on incidence,symptoms,diagnosis,risk factors,pathogenesis and treatment of ICIs-related colitis. |
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| Keywords: | Immune Checkpoint Inhibitors Adverse Drug Reaction Diarrhea Colitis |
| 本文献已被 CNKI 维普 等数据库收录！ |
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