2型糖尿病视网膜病变患者超敏C反应蛋白、血脂指标变化及相关危险因素分析

目的:观察2型糖尿病视网膜病变(DR)患者超敏C反应蛋白(hs-CRP)、血脂代谢相关指标变化,并分析其危险因素。方法:回顾性分析2018-02—2019-08本院收治的161例2型糖尿病(T2DM)患者,将其分成A组(Ⅰ型,未发生视网膜病变,62例);B组[Ⅱ、Ⅲ型,非增殖性的糖尿病性视网膜病变(NPDR),43例];C组[Ⅳ、Ⅴ型,增殖性的糖尿病性视网膜病变(PDR),56例],以同期体检健康者52例作为对照组。比较各组hs-CRP、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)及TG/HDL-C、TC/HDL-C、LDL-C/HDL-C比值水平变化差异,采用Spearman分析hs-CRP与各检测指标的相关性,Logistic回归分析DR可能的危险因素。结果:除LDL-C,hs-CRP、血脂代谢(TG、TC、HDL-C)及比值(TG/HDL-C、TC/HDL-C、LDL-C/HDL-C)在各组间比较,差异有统计意义(均P<0.05)。DR患者血液hs-CRP与TG(r=0.505)、TC(r=0.236)、LDL-C(r=0.313)、TG/HDL-C(r=0.50)、TC/HDL-C(r=0.385)、LDL-C/HDL-C(r=0.405)水平均呈正相关(均P<0.05),Logistic回归模型分析发现除了TC外其余各项指标均为T2DM患者发生DR的可能危险因素。结论:DR患者hs-CRP和血脂代谢指标对评估DR患者风险具有预测价值。

Analysis of Parameters and Ratios of High-sensitivity C-reactive Protein and Lipids and Risk Factors in Patients with Type 2 Diabetic Retinopathy

Objective:To analyze the changes of high-sensitivity C-reactive protein(hs-CRP),lipid metabolism related parameters and ratio in patients with type 2 diabetic retinopathy(DR).Method:A retrospective analysis of 161 patients with type 2 diabetes(T2DM)admitted to our hospital from February 2018 to August 2019 was divided into group A(type I,62 cases without retinopathy);group B[types II,III,Non-proliferative diabetic retinopathy(NPDR),43 cases];Group C[Types IV and V,proliferative diabetic retinopathy(PDR),56 cases],52 healthy people during the same period were selected as the healthy control group.The levels of hs-CRP,total cholesterol(TC),triglyceride(TG),high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C)and TG/HDL-C,TC/HDL-C,and LDL-C/HDL-C ratios were compared in each group.Spearman and Logistic regression were used to analyze the correlation between hs-CRP and other indicators,the possible risk fators of DR.Results:Except of LDL-C,hs-CRP,blood lipid metabolism(TG,TC,HDL-C)and ratio(TG/HDL-C,TC/HDL-C,LDL-C/HDL-C)were compared between the groups,and the differences were statistically significant(all P<0.05).The blood hs-CRP and TG,TC,LDL-C,TG/HDL-C,TC/HDL-C,LDL-C/HDL-C a certain positive correlation(all P<0.05).The Logistic analysis found that all indicators except TC were possible risk factors for DR in T2DM patients.Conclusion:The hs-CRP and lipid metabolism were predictive diagnostic value for assessing the risk of DR patients.