| 白细胞介素-6基因-174C/G和-634C/G多态性与尘肺易感性的Meta分析 |
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| 引用本文： | 郝艳星,李江平,史新琛,谢群慧,赵斌,徐海明,杨惠芳. 白细胞介素-6基因-174C/G和-634C/G多态性与尘肺易感性的Meta分析[J]. 卫生研究, 2020, 0(2): 185-189 |
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| 作者姓名： | 郝艳星 李江平 史新琛 谢群慧 赵斌 徐海明 杨惠芳 |
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| 作者单位： | 1.宁夏医科大学公共卫生与管理学院;2.中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室 |
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| 基金项目： | 国家自然科学基金(No.81660527);宁夏高等学校科学研究项目(No.NGY2016126);宁夏自然科学基金(No.NZ17059);宁夏高等学校一流学科建设(No.NXYLXK2017B08);中国科学院开放课题(No.KF-2015-011)。 |
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| 摘 要： | 目的探索白细胞介素-6(interleukin-6,IL-6)基因-174C/G和-634C/G多态性与尘肺易感性的关系。方法以尘肺、白细胞介素-6及多态性为关键词,检索中文数据库Sinomed、万方医学、中国知网和维普;以pneumoconiosis、interleukin-6及polymorphism为关键词,检索英文数据库Pubmed、Embase、Cochrane Library和Web of Science。采用Revman Manager 5.2软件进行效应值的合并和文献质量评价。结果共纳入7篇文献(9组病例-对照研究),包括IL-6基因-174C/G位点病例660例,对照848例;IL-6基因-634C/G位点病例344例,对照362例。Meta分析结果表明,IL-6基因-174C/G位点多态性与尘肺易感性之间无关联(CC对CG+GG,OR=1.05(95%CI 0.76～1.45), CG对GG+CC,OR=0.79(95%CI 0.40～1.55), C对G,OR=0.95(95%CI 0.80～1.14))。IL-6基因-634 C/G多态性位点与尘肺发病之间有关联...
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| 关 键 词： | 尘肺 白细胞介素-6 基因多态性 Meta分析 |
Meta-analysis on association between interleukin-6-174C/G and -634C/G polymorphisms and pneumoconiosis susceptibility |
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| Hao Yanxing,Li Jiangping,Shi Xinchen,Xie Qunhui,Zhao Bin,Xu Haiming,Yang Huifang. Meta-analysis on association between interleukin-6-174C/G and -634C/G polymorphisms and pneumoconiosis susceptibility[J]. Journal of hygiene research, 2020, 0(2): 185-189 |
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| Authors: | Hao Yanxing Li Jiangping Shi Xinchen Xie Qunhui Zhao Bin Xu Haiming Yang Huifang |
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| Affiliation: | (Public Health and Management of Ningxia Medical University,Yinchuan 750004,China;State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China) |
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| Abstract: | OBJECTIVE To explore the association between the interleukin-6-174 C/G and-634 C/G polymorphisms and pneumoconiosis susceptibility.METHODSTaking pneumoconiosis,interleukin-6,and polymorphism as keywords,Chinese literatures were retrieved among the Sinomed,Wanfang Medicine,CNKI and VIP databases,and foreign language literatures were retrieved among the Pubmed,Embase,Cochrane Library and Web of Science databases.Taking pneumoconiosis,susceptibility,and interleukin-6 as keywords,Revman 5.2 software was employed to combine the genetic effects and evaluate the quality of the included literatures.RESULTS A total of seven literatures(containing nine case-control studies)were included,including 660 cases and 848 controls with IL-6-174 C/G polymorphism,and 344 cases and 362 controls with IL-6-634 C/G polymorphism.Meta-analysis shows that IL-6-174 C/G polymorphism is not associated with pneumoconiosis susceptibility(CCνs.CG+GG,OR=1.05(95%CI 0.76-1.45),CGνs.GG+CC,OR=0.79(95%CI 0.40-1.55),Cνs.G,OR=0.95(95%CI 0.80-1.14)),while IL-6-634 C/G polymorphism is associated with pneumoconiosis susceptibility(CCνs.CG+GG,OR=2.12(95%CI 1.56-2.88),CGνs.GG+CC,OR=0.40(95%CI 0.27-0.58),Cνs.G,OR=1.67(95%CI 1.33-2.11)).CONCLUSION There exists an association between the IL-6-634 C/G polymorphism and pneumoconiosis susceptibility,while there isn’t an association between the IL-6-174 C/G polymorphism and the susceptibility of pneumoconiosis.IL-6-634 C/C genotype is pneumoconiosis-susceptible genotype. |
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| Keywords: | pneumoconiosis interleukin-6 polymorphism Meta-analysis |
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