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| 碳酸钙泡腾颗粒的人体生物利用度研究 | |
| 引用本文： | 周天杰,洪诤,程小宁,赵劲松,何文淑,熊宏智.碳酸钙泡腾颗粒的人体生物利用度研究[J].中国医院药学杂志,1998,18(12):533-535. |
| 作者姓名： | 周天杰 洪诤 程小宁 赵劲松 何文淑 熊宏智 |
| 作者单位： | 1. 华西医科大学附属职业病防治院,成都,610041 2. 华西医大药学院 3. 四川健益医药工业研究所 |
| 摘 要： | 目的：评价碳酸钙泡腾颗粒的人体生物利用度。方法：以原子吸收光谱法测定１０名健康志愿者口服碳酸钙泡腾颗粒与进口碳酸钙片后的尿钙浓度，以尿钙总排泄量与尿钙增量为指标评价两种制剂吸收差异。结果：口服１．２ｇ碳酸钙泡腾颗粒与碳酸钙片后４ｈ尿钙总排泄量分别为０．１４３ｍｇ·（ｍｇＣｒ）－１与０．１０９ｍｇ·（ｍｇＣｒ）－１；尿钙增量分别为０．０５１ｍｇ·（ｍｇＣｒ）－１与０．０３１ｍｇ·（ｍｇＣｒ）－１，前者均显著高于后者（Ｐ＜０．０５和Ｐ＜０．０１）。结论：碳酸钙泡腾颗粒的口服生物利用度高于碳酸钙片。 |
| 关 键 词： | 碳酸钙泡腾颗粒，尿钙，生物利用度 |
The bioavailability of calcium carbonate effervescent granules in healthy volunteers |
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| Zhou Tianjie,Hong Zheng,Cheng Xiaoning,et al.The bioavailability of calcium carbonate effervescent granules in healthy volunteers[J].Chinese Journal of Hospital Pharmacy,1998,18(12):533-535. | |
| Authors: | Zhou Tianjie Hong Zheng Cheng Xiaoning |
| Abstract: | Objective:To investigate the bioavailability of calcium carbonate effervescent granules in healthy volunteers.Methods:The urinary calcium were determined by atomic absorption spectrophotometry after a single oral dose of calcium carbonate effervescent granules and calcium carbonate tablet was given to 10 healthy volunteers.Results:The urinary calcium following calcium carbonate effervescent granules was significantly higher whether expressed as the total amount or as the increment above basal (fasting) excretion.Conclusion:The bioavailability of calcium carbonate effervescent granules was higher than calcium carbonate tablet. |
| Keywords: | calcium carbonate effervescent granules bioavailability |
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