Impact of EGFR and p53 expressions on survival and quality of life in locally advanced oral squamous cell carcinoma patients treated with chemoradiation |
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| Authors: | Seema Gupta Huma Khan Vandana Singh Kushwaha Nuzhat Husain MPS Negi Ashim Ghatak MLB Bhatt |
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| Affiliation: | 1.Department of Radiotherapy; King George''s Medical University; Lucknow, UP, India;2.Department of Pathology; RMLIMS; Lucknow, UP, India;3.Clinical and Experimental Medicine Division; CSIR-Central Drug Research Institute; Lucknow, UP, India |
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| Abstract: | EGFR and p53 are molecular markers which play important role in tumor progression and development. The objective of this study was to assess the association between EGFR and p53 expression and survival, and to determine whether EGFR and p53 expression levels were associated with differences quality of life in OSCC patients undergoing chemoradiation. A total of 120 OSCC patients aged 20–67 y and stage III/IV were recruited. Treatment response was assessed according to W.H.O. (1979). EGFR and p53 expression in tumor tissue was estimated by immunohistochemical (IHC) method and quantified as percentage positive nuclei. Molecular marker expressions of both EGFR and p53 were found significantly (P < 0.01 or P < 0.001) associated with overall response, survivals and quality of life. Neither EGFR nor p53 expression was associated with hematologic or non-hematologic toxicity. EGFR and p53 molecular marker expressions may have significant association with survival and QOL in OSCC patients undergoing chemoradiation. |
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| Keywords: | chemoradition immunohistochemistry oral squamous cell carcinoma quality of life survival endpoints toxicity |
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