老年高血压伴餐后高血糖患者炎症因子的变化及临床意义

目的探讨老年高血压伴餐后高血糖患者炎症因子变化及临床意义。方法采用放射免疫分析法测定血清肿瘤坏死因子-α（TNF—α）和白介素-6（IL-6），采用胶乳免疫增强比浊法测定高敏C反应蛋白（hs—CRP）。对40例老年高血压伴餐后高血糖患者、45例老年高血压不伴餐后高血糖（高血压组）患者及30例正常对照者进行比较。结果老年高血压伴餐后高血糖组血清TNF—α、IL-6和hs—CRP水平分别为（30．25±6．49）pg／ml、（19．91±5．22）pg／ml和（9．96±0．69）mg／L；高血压组分别为（19．11±3．01）pg／ml、（12.31±3．57）pg／ml和（6．79±0．25）mg／L；正常对照组分别为（8．18±2．89）pg／ml、（2．55±1．67）pg／ml和（3．06±0．23）mg／L；高血压伴餐后高血糖组高于对照组，也高于高血压组（P〈0．01）。结论老年高血压伴餐后高血糖患者炎症反应较不伴餐后高血糖的老年高血压患者严重，提示在降压的同时还应积极控制餐后高血糖以减轻炎症反应，延缓老年高血压患者病情进展。

Change and clinical significance of inflammatory factors in senile hypertensive patients with postprandial hyperglycemia

Objective To explore the change and clinical significance of inflammatory factors in senile hypertensive patients with postprandial hyperglycemia. Methods Serum TNF-α and IL-6 levels were measured with RIA, hs-CRP level was measured with immunochemistry method. The results were compared in 40 senile hypertensive patients with postprandial hyperglycemia, 45 senile hypertensive patients without postprandial hyperglycemia （hypertension group） and 30 normal controls. Results Serum TNF-α, IL-6 and hs-CRF levels in senile hypertensive patients with postprandial hyperglycemia group were （30.25±6.49）pg/ml, （19.91±5.22）pg/ml and （9.96±0.69）mg/L, hypertension group were （19.11±3.01）pg/m], （12.31±3.57）pg/ml and （6.79±0.25）mg/L, normal control group were（ 8.18±2.89 ）pg/m], （ 2.55±1.67 ）pg/m] and （ 3.06±0.23 ）mg/L. The hypertensive patients with postprandial hyperglycemia group was higher than control group and hypertension group（P〈0.01 ）. Conclusion The inflammatory reaction in senile hypertensive patients with postprandial hyperglycemia is severe than senile hyportensive patients without postprandial hyperglycemia. It indicates that beside reduce the blood pressure, postprandial hyperglycemia should be controlled at the same time in order to alleviate inflammatory reaction and slow the progress of illness in senile hypertensive patients.