| IL-18在寻常型银屑病患者皮损中的表达及其意义 |
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| 引用本文： | 李常兴,罗权,何玉清,韩春雷,张锡宝.IL-18在寻常型银屑病患者皮损中的表达及其意义[J].岭南皮肤性病科杂志,2009,16(3):158-160. |
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| 作者姓名： | 李常兴 罗权 何玉清 韩春雷 张锡宝 |
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| 作者单位： | 1. 广东省东莞市慢性病防治院,广东,东莞,523008
2. 广东省广州市皮肤病防治所,广东,广州510095 |
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| 基金项目： | 广东省医学科学技术研究基金 |
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| 摘 要： | 目的：探讨白细胞介素18（Interleukin 18，IL-18）在寻常型银屑病患者皮损中的表达及其意义。方法：采用荧光定量聚合酶链反应法测定20例寻常型银屑病患者皮损中和17例正常对照者皮肤中IL-18mRNA的定量表达，采用直线相关回归分析方法分析IL-18mRNA的表达与寻常型银屑病病情严重指数（PASI）的关系。结果：寻常型银屑病皮损内IL-18mRNA明显高于正常对照者皮肤中的表达水平（U=-4．7698，P〈0．001）。寻常型银屑病皮损内IL-18mRNA的表达与患者PASI呈显著的正相关（r=0．96258，P〈0．001）。结论：IL-18的表达上调可能与寻常型银屑病的发生、发展有关。
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| 关 键 词： | 寻常型银屑病 白细胞介素18 荧光定量聚合酶链反应 |
Investigation on the Expression and Clinical Significant of IL-18 in Patient with Psoriasis Vulgaris |
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| LI Chang-xing,LUO Quan,HE Yu-qing,HAN Chun-lei,ZHANG Xi-bao.Investigation on the Expression and Clinical Significant of IL-18 in Patient with Psoriasis Vulgaris[J].Southern China Journal of Dermato-Venereology,2009,16(3):158-160. |
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| Authors: | LI Chang-xing LUO Quan HE Yu-qing HAN Chun-lei ZHANG Xi-bao |
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| Institution: | 1. Dongguan Hospital of Chronic Disease;Dongguan 523008;China;2. Guangzhou Institute of Dermatology;Guangzhou 510095;China |
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| Abstract: | Objective:To study the expression and clinical significance of interleukin 18(IL-18) in psoriatic lesional skin. Methods:Twenty adult patients with psoriasis vulgaris and 17 health control were sequentially enrolled in this study. The production IL-18 mRNA was measured by fluorescent quantitative polymerase chain reaction. The relationship between IL-18 and disease severity(PASI) was assessed by correlation analysis.Results:Expression of IL-18 mRNA in psoriatic lesional skin was higher than that in control ... |
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| Keywords: | Psoriasis vulgaris Interleukin 18 fluorescent quantitative polymerase chain reaction |
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