五味子油对2型糖尿病大鼠胰岛素抵抗的影响

目的研究五味子油对2型糖尿病胰岛素抵抗大鼠的血糖、血脂和胰岛素的影响,并初步探讨其作用机制。方法以高糖高脂饲料联合小剂量链脲佐菌素(STZ)诱导建立2型糖尿病大鼠胰岛素抵抗模型。随机分为正常组,模型组,五味子油高(1 mg/kg)、低剂量(0.5 mg/kg)组,罗格列酮组。连续灌胃6周,测定空腹血糖(FBG)、空腹胰岛素(FINS)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDH)、总胆固醇(TC)水平,并计算胰岛素抵抗指数(HOMA-IR)。结果五味子油可降低糖尿病大鼠FBG、TG、LDH、TC、FINS水平,升高HDL的含量,降低HOMA-IR。结论五味子油对2型糖尿病大鼠有降低血糖调节血脂代谢紊乱,改善胰岛素抵抗的作用。

Effect of Schisandrae chinenesis oil on type 2 diabetes rats with insulin resistance

Purpose To study the effects of Schisandrae chinenesis oil on serum glucose,serum lipid and insulin in type 2 diabetes rats with insulin resistance,and to try to find out its mechanism.Methods The high-fat diet combined with low-dose STZ at the ideal interval was used to establish the experimental rat model of type 2 diabetes.Rats were randomly divided into nomal group,model group,Schisandrae chinenesis oil 1 and 0.5 mg/kg groups and rosiglitazone group.Fasting blood glucose(FBG),fasting insulin(FINS),triglyceride(TG),high-density liporotein(HDL),low-density liporotein(LDL),and total cholesterol(TC) were measured after 6 weeks,and the insulin resistance index(HOMA-IR) was calculated.Results Schisandrae chinenesis oil could obviously decrease FBG,TG,LDH,TC,and FINS,increase HDL,and decrease HOMA-IR.Conclusion Schisandrae chinenesis oil has a treatment effect on diabetes type 2 rats with insulin resistance.It could decrease FBG and adjust metabolic disturbance,and improve insulin resistance.