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Recombinant protein-based assays for detection of antibodies to severe acute respiratory syndrome coronavirus spike and nucleocapsid proteins |
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| Authors: | Haynes Lia M Miao Congrong Harcourt Jennifer L Montgomery Joel M Le Mai Quynh Dryga Sergey A Kamrud Kurt I Rivers Bryan Babcock Gregory J Oliver Jennifer Betts Comer James A Reynolds Mary Uyeki Timothy M Bausch Daniel Ksiazek Thomas Thomas William Alterson Harold Smith Jonathan Ambrosino Donna M Anderson Larry J |
| Affiliation: | National Centers for Immunization and Respiratory Diseases, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Mailstop G-18, Atlanta, GA 30333. loh5@cdc.gov |
| Abstract: | Recombinant severe acute respiratory syndrome (SARS) nucleocapsid and spike protein-based immunoglobulin G immunoassays were developed and evaluated. Our assays demonstrated high sensitivity and specificity to the SARS coronavirus in sera collected from patients as late as 2 years postonset of symptoms. These assays will be useful not only for routine SARS coronavirus diagnostics but also for epidemiological and antibody kinetic studies. |
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