早期持续小剂量静滴纳洛酮对早产极低体质量儿呼吸暂停的干预

目的观察持续小剂量静脉滴注纳洛酮对早产极低体质量儿呼吸暂停的干预作用。方法2005～2008年共收治早产极低体质量儿63例，随机分为治疗组和对照组。治疗组33例，生下后尚未发生呼吸暂停时即给予小剂量纳洛酮5μg·kg^-1·h^-1持续静脉滴入；对照组30例，生后发生呼吸暂停才使用纳洛酮持续静脉滴入。两组在1周内观察呼吸暂停的次数、用氧平均时间及用机械通气百分率，并观察用纳洛酮后的不良反应及安全性。结果治疗组在1周内有8例（8％）发生呼吸暂停，对照组组有15例（50％）发生呼吸暂停，两组比较有统计学意义（χ^2=4．49，P〈0．05）；治疗组平均用氧时间（7±3）d，对照组（10±2）d，两组比较差异有统计学意义（χ^2=7．928，P〈0．001）；治疗组机械通气4例（12．12％），对照组10例（33％），两组对比差异有统计学意义（χ^2=4．091，P〈0．05）。结论持续小剂量静脉滴注纳洛酮对早产极低体质量儿呼吸暂停有明显的干预作用且安全。

Preventive effect of little dose of aminophylline in apnea of abortive VLBWI

Objective To evaluate the effect of little dose aminophylline in preventing apnea of abortive VLBWI.Methods During 2005 to 2008,63 cases of VLBWI were divided randomly into two groups.33 cases in the treatment group was administered at a dose of 0.005mg/kg by intravenous pumping when apnea did not appear after birth.Another group composed of 30 cases was treated with aminophylline only on set of apnea after birth.The time of apnea of both the groups have been observed for one week by using oxygen and the ra...