冠心病患者血脂及载脂蛋白水平的关系

目的:观察冠心病患者血脂及载脂蛋白变化及相互关系,以探索血脂及载脂蛋白水平在冠心病诊断中的应用价值。方法:观察100例确诊的冠心病患者及25例健康查体者血脂及载脂蛋白水平,利用全自动生化分析仪测定血清甘油三脂(TG)、总胆固醇(CH)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、脂蛋白a(Lpa)、载脂蛋白A1(ApoA1)、载脂蛋白A2(ApoA2)、载脂蛋白B(ApoB)、载脂蛋白C2(ApoC2)、载脂蛋白C3(ApoC3)、载脂蛋白E(ApoE)。结果:冠心病患者血清Lp(a)高于正常人群(P<0.05);CH、HDL、ApoA1、ApoA2水平显著低于正常人群(P<0.01)。女性冠心病患者血清CH、HDL、ApoA1水平显著高于男性冠心病患者(P<0.01)。不同年龄组冠心病患者血脂水平的比较发现随年龄的增长,血脂代谢变缓,血脂水平有降低趋势。结论:冠心病患者血清多项脂类规律性变化,提示血脂及载脂蛋白水平的监测对于冠心病的诊断及预后具有重要的意义。

Study on the serum lipd and apolipoprotein level in patients with coronary heart disease

Objective:The significance of serum lipids and apolipoprotein in coronary heart disease have been evaluated.Methods: The serum lipids and apolipoprotein in level of TG,CH,HDL,LDL,Lp(a),ApoA1,ApoA2,ApoB,ApoC2,ApoC3 and ApoE in 100patients and 25 matched healthy volunteers have been observed.Serum lipid and apolipoprotein level had been measured on automatic biochemistry analyzer.Results: The serum Lp(a)increased in patients group(P<0.05),whereas serum level of CH,HDL,ApoA1,ApoA2 decreased(P<0.01).The serum concentration of CH,HDL,ApoA1 in female patients increased compared with male patients.Conclusion:The variation of serum lipids and apolipoprotein level showed that monitoring the lipids and apolipoprotein levels has clinical significance to diagnose and follow up these patients.