血清NSE及其半衰期诊断与监测小细胞肺癌的评价

目的:评价小细胞肺癌(SCLC)患者血清神经元特异性烯醇化酶(NSE)在该病的诊断、化疗和复发中的意义以及NSE半衰期与SCLC复发的关系。方法:用双抗体夹心ELISA法测定NSE含量。结果:NSE诊断SCLC的敏感性、特异性及准确度分别为85.0%、85.3%、88.7%;其中局限期(LS)SCLC和广泛期(ES)SCLC患者的阳性率分别为71.4%、92.3%,NSE半衰期大于20 d者,其复发在发病前为47~183 d前即被发现,NSE的半衰期预测SCLC复发敏感性为80.0%。结论:血清NSE检测对SCLC与NSCLC的鉴别诊断具有重要意义,NSE半衰期预测SCLC复发的敏感性优于NSE含量测定。

Evaluation of serum neuron-specific enolase and its half-life analysis in diagnosis and follow-up of small cell lung cancer

Objective:To evaluate the clinical value of detection of serum neuron-specific enolase(S-NSE) level and its half-life in differential diagnosis monitoring of chemotherapy and prediction of relapse of small cell lung cancer(SCLC).Methods: The double mAb sandwich ELISA was used.Results: The sensitivity,specificity,and accuracy of the ELISA tests for detection of serum NSE were 85.0%,85.3%,88.7% respectively.The positive rates of serum NSE detected in limited stage(LS) and extensive stage(ES) patients with SCLC were 71.4%,92.3%;The patients whose serum NSE half-life were more than 20ds,the relapse would found from 47-183d since they had been found to be SCLC,the sensitivity of prediction of relapse by half-life of NSE was 80.0%.Conclusion: Detection of serum NSE level is of significance in differentiation between SCLC and NSCLC.The half-Life of serum NSE predicting the relapse of SCLC is better than the detection of serum NSE.