恶性肿瘤患者血清酶活性分析

目的:评价恶性肿瘤患者血清中丙氨酸氨基转移酶(GPT)、天门冬氨酸氨基转移酶(GOT)、乳酸脱氢酶(LDH)、碱性磷酸酶(ALP)和γ-谷氨酰氨基转移酶(GGT)等5种酶活性的变化规律和相互关系,为恶性肿瘤的辅助诊断提供参考。方法:利用Hitachi全自动生化分析仪对373例临床病理确诊恶性肿瘤患者血清酶活性进行了测定。结果:在恶性肿瘤患者血清5种酶类都有不同程度升高。对8种恶性肿瘤实验诊断的5种血清酶中3个主要成分是:原发性肝癌91.3%:GGT-GOT-LDH;乳腺癌89.5%:GGT-GOT-LDH;肺癌90.2%:GOT-ALP-LDH;胃癌94.1%:GOT-LDH-GGT;结肠癌95.8%:GOT-GGT-LDH;直肠癌96.1%:GGT-ALP-LDH;胰腺癌93.2%:GGT-LDH-ALP;胆道恶性肿瘤96.2%:GOT-GGT-AL。结论:联合检测可提高检测的敏感性,因此在不明原因血清酶活性升高时,应考虑肿瘤可能性。

Statistic analysis on activities of serum enzymes in patients with malignant tumor

Objective:To evaluate the variation profiling of serum enzymes from 8 malignant tumor. Methods:The activities of serum GPT, GOT, LDH, ALP and GGT from 373 malignant tumor patients were measured by HITACHI 7600 automatic biochemistry analyzer. Results:The 3 principal components among the 5 enzymes and their positive rate for each cancer were: primary liver cancer 91.3%:GGT-GOT-LDH, breast cancer 89.5%: GGT-GOT-LDH, lung cancer 90.2%: GOT-ALP-LDH, gastric cancer 94.1%: GOT-LDH-GGT, colon cancer 95.8%: GOT-GGT-LDH, rectum cancer 96.1%: GGT-ALP-LDH, pancreas cancer 93.2%: GGT-LDH-ALP,and bile duct tumor 96.2%: GOT-GGT-ALP. Conclusion: The association tests of the enzymes give better and more sensitive results to tumor diagnosis. The increased serum enzyme activity without supported clinical reason may be indicating the risk of tumor.