| 葡参延年康片体内抗氧化作用的实验研究 |
| |
| 引用本文： | 魏日胞,李建军,高卓,洪权. 葡参延年康片体内抗氧化作用的实验研究[J]. 军医进修学院学报, 2007, 28(1): 15-16 |
| |
| 作者姓名： | 魏日胞 李建军 高卓 洪权 |
| |
| 作者单位： | 解放军总医院,全军肾脏病研究所暨重点实验室,北京,100853 |
| |
| 基金项目： | 解放军医药卫生科研项目 |
| |
| 摘 要： | 目的:探讨葡参延年康片抗氧化、清除体内自由基的生物效应。方法:将10月龄昆明种小鼠随机分为对照组和葡参延年康片低、中、高剂量组,每组12只。连续灌胃给药40 d,采血,测定丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)活力和超氧化物歧化酶(SOD)的活力;测定心肌脂褐质和肝脏乳酸过氧化物酶(LPO)含量。结果:葡参延年康片可减少MDA、心肌脂褐质和肝脏LPO含量(P<0.05),增强GSH-Px和SOD活性(P<0.05)。结论:葡参延年康片可有效清除体内的氧自由基,具有减少氧化应激引起的器官损伤和延缓机体衰老的潜能。
|
| 关 键 词： | 葡参延年康片 抗氧化剂 小鼠 |
| 文章编号： | 1005-1139（2007）01-0015-02 |
| 收稿时间： | 2006-07-27 |
| 修稿时间： | 2006-08-31 |
Experimental study of the antioxygenation activity of Pu shen- yan-nian-kang-pian in vivo |
| |
| WEI Ri-bao,LI Jian-jun,GAO Zhuo,HONG Quan. Experimental study of the antioxygenation activity of Pu shen- yan-nian-kang-pian in vivo[J]. Academic Journal of Pla Postgraduate Medical School, 2007, 28(1): 15-16 |
| |
| Authors: | WEI Ri-bao LI Jian-jun GAO Zhuo HONG Quan |
| |
| Abstract: | Objective:To investigate the antioxygenation of Pu shen-yan-nian-kang-pian(PSYNK) via scavenging oxygen free radical in vivo.Methods:Forty-eight mice were randomly divided into vehicle control,low,middle and high PSYNK dosage groups and administered test material or vehicle for 40 days.Then,venous blood was sampled for measurement of serum malonaldehyde(MDA),activity of superoxide dismutase(SOD) and lutathione peroxidase(GSH-Px),and heart and hepar tissue were collected to detect the content of lipofuscin and lactoperoxidase(LPO),respectively.Results:Compared with vehicle control group,PSYNK could activate SOD and GSH-Px,decrease the content of serum MDA,cardiac muscle lipofuscin as well as hepar LPO.Conclusion: PSYNK can scavenge oxygen free radical effectly in vivo and have the potential effect to prevent organs from oxidative stress damage during aging course. |
| |
| Keywords: | Pu shen-yan-nian-kang-pian antioxidants mouse |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
