头孢羟氨苄甲氧苄啶胶囊溶出度测定

目的：建立头孢羟氨苄甲氧苄啶胶囊溶出度测定方法。方法：以盐酸溶液（9→1000）为溶出介质，采用高效液相色谱法测定其溶出度。结果：头孢羟氨苄的浓度在38．6～192．8μg·ml^-1内呈良好的线性关系，r=1．0000，平均回收率为99．1％（RSD=0．3％，n=10）；；甲氧苄啶的浓度在7．8～39．0μg·ml^-1内呈良好的线性关系，r=0．9999，平均回收率为98．9％（RSD=0．5％，n=10）.结论：方法准确、简便，可作为制剂的溶出度测定方法。

Determination the Dissolution of Cefadroxil and Trimethoprim Capsules

Objective： To establish the method for the determination the dissolution for cefadroxil and trimethoprim capsules. Method： The dissolution rates were determined by HPLC, the hydrochloride acid solution （9→1000）as dissolution medium was used.Result： The linear ranges of cefadroxil and trimethoprim were 38.6 - 192.8μg·ml^-1 , r = 1. 000 0 and 7.8 - 39.0μg·ml^-1, r = 0.999 9. the average recoveries （n = 10） were 99.1% （RSD% = 0.3 % ） and 98.9% （RSD = 0.5 % ）, respectively. Conclusion： The method is accurate, and simple, it can be used for determination method of dissolution of cefadroxil and trimethoprim capsules.