Relative absorption of the two enantiomers of terbutaline after duodenal administration |
| |
| Authors: | L. Borgström B. -M. Kennedy B. Nilsson B. Angelin |
| |
| Affiliation: | (1) Explorative Clinical Research, AB Draco, Lund, Sweden;(2) Bioanalytics Laboratory, AB Draco, Lund, Sweden;(3) Department of Radiology, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden;(4) Metabolism Unit, Department of Medicine, Karolinska Institutet at Huddinge University Hospital, Huddinge, Sweden |
| |
| Abstract: | Summary The absorption of the two enantiomers of terbutaline, (+)-terbutaline and (-)-terbutaline, and of the racemate, (±)-terbutaline, has been studied in six healthy volunteers using a newly developed intestinal perfusion technique.The area under the plasma concentration curve for the (-)-enantiomer was more than twice that for the (+)-enantiomer.The data demonstrate a clear difference in absorption efficiency between (-)- and (+)-terbutaline, but further studies are required to establish whether (-)-terbutaline influences the absorption of (+)-terbutaline. |
| |
| Keywords: | terbutaline absorption enantiomers |
| 本文献已被 SpringerLink 等数据库收录！ |
|
