Examination of bone marrow biopsy specimens and staging of small cell lung cancer |
| |
| Affiliation: | 1. Department of Pylmonology, Academic Hospital Maastricht, 6201 BX Maastricht, The Netherlands;2. Department of Pathology, Academic Hospital Maastricht, 6201 BX Maastricht, The Netherlands;3. Department of Medical Statistics, Academic Hospital Maastricht, 6201 BX Maastricht, The Netherlands;1. Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, MRW, Charlottesville, VA, United States;2. Clarient Pathology Services, Aliso Viejo, CA, United States;3. M.D. Anderson Cancer Center, DPO, Houston, TX, United States;1. Unit of Lymphoid Malignancies, Department of Onco-Hematology, IRCCS San Raffaele Scientific Institute, Milano, Italy;2. Pathology Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy;3. Università Vita e Salute, IRCCS San Raffaele Scientific Institute, Milano, Italy;1. Department of Otorhinolaryngology, Nishi-Kobe Medical Center, Kobe, Japan;2. Department of Otorhinolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Japan;3. Department of Pathology, Nishi-Kobe Medical Center, Kobe, Japan;4. Department of Anatomic Pathology, Tokyo Medical University, Tokyo, Japan;1. Faculty of Food Engineering, University of Campinas (UNICAMP), Rua Monteiro Lobato 80, 13083-862 Campinas - SP, Brazil;2. Institute of Food Technology (ITAL), Avenida Brasil 2880, C. P. 139, 13070-178 Campinas - SP, Brazil;3. Sciensano, Leuvensesteenweg 17, 3080 Tervuren, Belgium;4. Ghent University, Laboratory of Analytical Chemistry and Applied Ecochemistry, Coupure links 653, 9000 Ghent, Belgium;1. Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan;2. Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan |
| |
| Abstract: | Bone marrow biopsy specimens were evaluated retrospectively in 63 of 88 (72%) patients with small cell lung cancer (SCLC). Significant differences were not found between extensive disease (ED) patients with or without bone marrow metastases in survival nor in nadirs of leucocytes or platelets subsequent to chemotherapy. A panel of antibodies was used to investigate whether immunohistochemical analysis on routinely processed bone marrow biopsy specimens could detect marrow metastases more effectively than conventional microscopy. In histologically proven marrow metastases and in control SCLC sections a combination of an antibody against cytokeratin 8, 18 and 19 (NCL5D3) and an antibody against neurone specific enolase was validated for detection of metastases. In histologically negative marrow biopsy samples, however, this combination did not yield any additional tumour positive cases. Therefore, histological evaluation of a bone marrow biopsy specimen, even when analysed by immunohistochemistry, does not contribute information relevant for staging, therapy evaluation or prognosis in SCLC. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
