Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants |
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| Authors: | Gemma Texidó ,Heinz Jacobs,Myriam Meiering,Ralf Kü hn,Jü rgen Roes,Werner Mü ller,Susan Gilfillan,Hiroshi Fujiwara,Hitoshi Kikutani,Nobuaki Yoshida,Ryuichi Amakawa,Christophe Benoist,Diane Mathis,Tadamitsu Kishimoto,Tak W. Mak,Klaus Rajewsky |
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| Abstract: | We show through sequence analysis of rearranged immunoglobulin variable (Ig-V) region genes from memory B cells of mouse mutants generated by gene targeting that terminal deoxynucleotidyl transferase, CD23, interleukin-4, IgD and CD30 are dispensable for somatic hypermutation. |
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| Keywords: | Hypermutation Terminal deoxynucleotidyl transferase CD23 Interleukin-4 IgD |
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