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| 阿西美辛缓释片的制备及体外释放度测定 | |
| 引用本文： | 沈颜红,解秀娣,徐秀娟. 阿西美辛缓释片的制备及体外释放度测定[J]. 中国医院药学杂志, 2005, 25(7): 634-636 |
| 作者姓名： | 沈颜红 解秀娣 徐秀娟 |
| 作者单位： | 1. 河北省胸科医院,河北,石家庄,050041 2. 唐山市丰润区第二人民医院,河北,唐山,063030 3. 河北省口腔医院,河北,石家庄,050017 |
| 摘 要： | 目的:制备阿西美辛缓释片并对其体外释放度进行研究.方法:采用4因素3水平正交试验设计法筛选、优化最佳处方,以进口缓释胶囊(优妥)为对照,采用转蓝法测定体外释放度,319 nm波长处UV法定量.结果:两剂型体外释药相似,释药方程分别为对照品F1=0.2032 0.197t1/2(r=0.9706),样品F2=0.1535 0.2971t1/2(r=0.9701).结论:以正交法优选的阿西美辛缓释片处方合理. |
| 关 键 词： | 阿西美辛 缓释片 释放度 正交设计 |
| 文章编号： | 1001-5213(2005)07-0634-03 |
| 收稿时间： | 2004-12-01 |
| 修稿时间： | 2004-12-01 |
Preparation of acemetacin extended release tablets and its drug release |
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| SHEN Yan-hong,XIE Xiu-di,XU Xiu-juan. Preparation of acemetacin extended release tablets and its drug release[J]. Chinese Journal of Hospital Pharmacy, 2005, 25(7): 634-636 | |
| Authors: | SHEN Yan-hong XIE Xiu-di XU Xiu-juan |
| Abstract: | OBJECTIVE To prepare acemetacin extended release tablets and to study the release property in vitro.METHODS The optimal formulation of the tablet was found with orthogonal experiment design and the imported acemetacin extended release capsule was the controlled capsule.RESULTS The release properties in vitro of the two were similar.The equations were F_1=0.203 2+0.197t~1/2(r=0.970 6) andF_2=0.153 5+0.297 1t~1/2 (r=0.970 1).CONCLUSION The formulation is reasonable. |
| Keywords: | acemetacin extended release tablets release property orthogonal design |
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