局部中晚期宫颈癌同步放化疗与单纯放疗疗效比较

目的：探讨并比较同步放化疗治疗局部中晚期宫颈癌的临床疗效及不良反应。方法选择初治Ⅱb-Ⅳa期宫颈癌患者120例，按随机数字表法分为同步放化疗组（放化组）60例和单纯放疗组（单放组）60例。观察两组的疗效和副反应，并做比较分析。结果两组近期有效率、5年生存率、局部复发率和远处转移率、胃肠道反应、骨髓抑制反应差异均有统计学意义（P＜0.05）；放射性直肠炎、膀胱炎差异无统计意义（P＞0.05）。结论同步放化疗能提高局部中晚期宫颈癌近期疗效，提高5年生存率，降低5年的局部复发率、远处转移率，但胃肠道反应及骨髓抑制反应增加明显。

Effects of synchronous chemoradiation therapy versus radiation therapy alone in the treatment of local medi-um-term and advanced cervical cancer

Objective To explore the synchronous chemoradiotherapy of clinical curative effect and adverse reaction of synchronous chemoradiation therapy in the treatment local medium-term and advanced cervical cancer . Methods According to random number table method ,one hundred and twenty patients withⅡb-Ⅳa cervical cancer receiving initial treatment were divide into synchronous chemotherapy group （60 cases） and simple radiotherapy group （ 60 cases ） .Results Between two groups there were statistically significant difference in short-term therapeutic effect,5-years′survival rate,local recurrence rate and distant metastasis rate in 5-year（P〈0.05）;and there were sta-tistically significant difference in gastrointestinal reaction,bone marrow suppression（P〈0.05）;no significant differ-ence were observed in the radiation proctitis and radioactive ,cystitis（P〉0.05）.Conclusion Synchronous chemora-diotherapy can improve short-term therapeutic effect of local medium-term advanced cervical cancer , improve the 5-year survival rate, reduce local recurrence rate and distant metastasis rate in 5-years,but significantly increase the gastrointestinal reaction and bone marrow suppression .