PCA3联合mMRI在前列腺癌诊断中的意义

目的探讨前列腺癌基因3（prostate cancer gene 3,PCA3）和多参数磁共振成像（multiparametric magnetic resonance imaging,mMRI）对前列腺癌的诊断意义。方法对56例首次穿刺结果为阴性但PSA持续升高的患者在第二次穿刺活检之前行PCA3和mMRI检查。评估PCA3评分和mMRI对前列腺癌诊断的准确性和可靠度及其对前列腺穿刺结果的预测性。结果 mMRI结果显示20例（35.7%）患者具有前列腺癌特征;PCA3评分（截断值为35时）显示15例（26.8%）患者疑为前列腺癌;前列腺穿刺活检结果显示23例（41.1%）患者确诊为前列腺癌。PCA3和mMRI对前列腺癌诊断的敏感性和特异性分别为67%、49%及74%、89%。结论 mMRI增加了PCA3对前列腺癌诊断的准确性和敏感性,可以减少不必要的前列腺穿刺。

The significance of PCA3 combining with mMRI in detecting of prostate cancer

Objective To evaluate the value of the urinary prostate cancer gene 3（PCA3）assay combining multiparametric magnetic resonance imaging（mMRI）in diagnosis of prostate cancer（PCa）. Methods A study of 56 patients with a longlasting high prostate-specific antigen level and previously negative biopsy was performed to assess the role of mMRI and PCA3 in identifying PCa,the accuracy and reliability were evaluated. Results mMRI showed that 20（35.7%）patients were may sufferer PCa;And PCA3 scores showed that 15（26.8%）cases may suffer from PCa;Repeated transrectal ultrasound（TRUS）-guided biopsy identified 23（41.1%）new cases of PCa.The sensitivity and specificity of PCA3 test and mMRI was 67%and 49%and 74%and 89%,respectively.The study showed that the model included mMRI and PCA3 had a better performance in predicting PCa. Conclusions mMRI can improve the accuracy and sensitivity of PCA3 for diagnosis of PCa,therefore,can avoid unnecessary biopsies.