| 血管升压素在脓毒性休克中的研究进展 |
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| 引用本文： | 薄禄龙,邓小明. 血管升压素在脓毒性休克中的研究进展[J]. 中国急救医学, 2007, 27(3): 249-251 |
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| 作者姓名： | 薄禄龙 邓小明 |
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| 作者单位： | 200433,上海,解放军第二军医大学附属长海医院麻醉科 |
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| 摘 要： | 血管升压素是维持心血管功能稳定的重要内源性物质。但脓毒性休克时,其在体内却相对不足,给予外源性血管升压素可引起显著的血管升压效应。目前,脓毒性休克时机体血管升压素缺乏以及机体对其敏感性增高的具体机制尚不清楚。目前研究认为,血管升压素受体改变、收缩和舒张血管因素、自主神经系统和下丘脑-垂体-肾上腺轴均参与了血管升压素高敏感性机制的调节。
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| 关 键 词： | 血管升压素 脓毒症 脓毒性休克 |
| 文章编号： | 1002-1949(2007)03-0249-03 |
| 修稿时间： | 2006-12-25 |
Study on vasopressin during septic shock |
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| BO Lu-long,DENG Xiao-ming. Study on vasopressin during septic shock[J]. Chinese Journal of Critical Care Medicine, 2007, 27(3): 249-251 |
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| Authors: | BO Lu-long DENG Xiao-ming |
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| Affiliation: | Department of Anesthe-siology, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Vasopressin is an important endogenous hormone for cardiovascular homeostasis. Vasopressin is relatively deficient during septic shock. In the circumstances, exogenous vasopressin can induce obvious vasopressor effects. Now the mechanisms of vasopressin deficiency and hypersensitivity in septic shock are unclear. The potential mechanisms underlying vasopressin hypersensitivity include changes of vasopressin receptors, interacting with other vasoconstriction/vasodilatation factors, autonomic nervous system and the hypothalamic-pituitary-adrenal axis. |
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| Keywords: | Vasopressin Sepsis Septic shock |
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