| 慢性肺心病红细胞变形性与红细胞膜流动性变化（附17例病例分析） |
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| 引用本文： | 苗会,林友华.慢性肺心病红细胞变形性与红细胞膜流动性变化（附17例病例分析）[J].中日友好医院学报,1993,7(3):174-176. |
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| 作者姓名： | 苗会 林友华 |
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| 作者单位： | 北京市垂阳柳医院(苗会，林友华，庄逢源)，中日友好医院呼吸内科(许越)，中日友好医院临床医学研究所血液流变室(许建军) |
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| 摘 要： | 用荧光偏振法测定17例慢性肺心病急性发作期患者及17名健康人红细胞膜流动性,用微孔泸膜法测定其中10例红细胞变形性。结果,肺心病患者及正常人红细胞膜微粘度分别为4.64±1.56及3.51±1.05η(p<0.05);红细胞滤速分别为384±136及233±97(p<0.01)。红细胞滤速与红细胞膜粘度间呈明显正相关(r=0.802,p<0.01)。结果提示,肺心病患者红细胞膜流动性下降可能对红细胞变形性下降起一定作用。
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| 关 键 词： | 肺心病 红细胞 红细胞膜 |
ALTERATION OF ERYTHROCYTE DEFORMABILITY AND ERYTHROCYTE MEMBRANE LIPID FLUIDITY IN CHRONIC COR PULMONALE WITH ACUTE EXACERBATION (A REPORT OF 17 CASES) |
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| Miao Hui,Lin Youhua,Zhuang Fengyuan,et al.ALTERATION OF ERYTHROCYTE DEFORMABILITY AND ERYTHROCYTE MEMBRANE LIPID FLUIDITY IN CHRONIC COR PULMONALE WITH ACUTE EXACERBATION (A REPORT OF 17 CASES)[J].Journal of China-Japan Friendship Hospital,1993,7(3):174-176. |
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| Authors: | Miao Hui Lin Youhua Zhuang Fengyuan |
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| Abstract: | Erythrocyte membrane lipid fluidity was determined in 17 health subjects and 17 cases of chronic cor pulmonale with acute exacerbation by polarization of fluorescence method. Erythrocyte deformability was studied in 10 cases. Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) and blood gases were measured simultaneously. Erythrocyte deformability, erythrocyte membrane lipid fluidty and MCHC were decreased. Erythrocyte deformability was positively correlated with erythrocyte membrane lipid fluidity (r=0. 802, p<0. 01), however erythrocyte deformability was correlated with PaO_2 negatively (r=-0. 807 p<0. 01). The results showed that the decrease of erythrocyte membrane lipid fluidity is one of the main factors for the decrease of erythrocyte deformability. |
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| Keywords: | chronic cor pulmonale erythrocyte deformability erythrocyte membrane lipld fluidity polarization of fluorescence |
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