普萘洛尔联合硝酸异山梨酯预防食管胃底曲张静脉再出血疗效观察

目的探讨普萘洛尔和硝酸异山梨酯联合治疗预防肝硬化食管胃底曲张静脉再出血的有效性。方法122例肝硬化食管胃底曲张静脉出血的患者被随机分成三组,一组为普萘洛尔+硝酸异山梨酯;一组为普萘洛尔;一组为对照组,观察其疗效。结果普萘洛尔+硝酸异山梨酯组12个月、18个月、24个月再出血率分别为7%、12%、28%;普萘洛尔组分别为22%、37%、49%;对照组分别为46%、58%、79%,三组间差异有统计学意义(P<0.05)。结论普萘洛尔联合硝酸异山梨酯能明显降低肝硬化门脉高压患者的再出血率。

Preventive effect of propanolol and cedocard on rehaemorrhagia of hepatic cirrhosis

Objective To evaluate the effects of preventing rehaemorrhagia of esophageal-gastric varication in hepatic cirrhosis cases by using propanolol and cedocard.Methods 122 cases of esophageal-gastric varices bleeding in hepatic cirrhosis were divided into 3 groups at random.One was propanolol and cedocard,the other was propanolol,the third was control group.Results During study,the rehaemorrhagia rate of propanolol and cedocard group was 7%,12%and 28% at 12 months,18 months,24 months respectively.The propanolol group was 22%,37%,49%.The control group was 46%,58%,79%.The rehaemorrhagia incidence rates were significantly different among three groups(P<0.05).Conclusion Propanolol and cedocard can lower the rehaemorrhagia rate of portal hypertension in hepatic cirrhosis cases.