Effect of blood on styrene oxidation in perfused rat liver |
| |
| Authors: | G Belvedere L Talve E Hietanen H Vainio |
| |
| Affiliation: | 1. Laboratory for Enzyme Research, Istituto di Ricerche Farmacologiche ‘Mario Negri’, Via Eritrea 62, 20157 Milan, Italy;2. Department of Physiology, University of Turku, SF-20520 Turku 52 Finland;3. Institute of Occupational Health, Haartmaninkatu I, 00290 Helsinki 29 Finland |
| |
| Abstract: | The oxidation of styrene to styrene oxide was studied in the isolated perfused rat liver in the presence and absence of blood at styrene concentrations of 2.5 and 50 mM. Erythrocytes contained in whole blood increased the levels of styrene glycol about 5 times after a short perfusion time with both concentrations. This increase was observed up to 1 h with 2.5 mM styrene. At both styrene concentrations styrene oxide was not detectable, either in the presence or absence of blood indicating that the liver was able completely to detoxify the styrene oxide produced by the mixed-function oxidases (MFO) and the oxyhemoglobin in the erythrocytes. |
| |
| Keywords: | Styrene styrene oxide oxyhemoglobin MFO mixed-function oxidases SCE sister chromatid exchange |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
