利培酮与氯丙嗪治疗精神分裂症的疗效及相关因素的比较

目的 :分析比较利培酮与氯丙嗪对精神分裂症的疗效及相关因素。方法 :用利培酮足量治疗55例精神分裂症病人 8wk ,以氯丙嗪治疗 52例病人作对照 ,采用PANSS量表评定 2药的疗效 ,所得资料行 χ2 ,t检验 ,多元回归分析。结果 :利培酮组、氯丙嗪组总有效率分别为 76 % ,88%。 2组对阳性症状、一般病理症状的疗效均优于对阴性症状的疗效 ,利培酮组疗效与用药剂量、家庭史、症状严重度有关 ,而氯丙嗪组疗效与这些因素无关。结论 :利培酮疗效与氯丙嗪相当 ,但其影响因素有别于后者。

Comparison of effects and factors between risperidone and chlorpromazine on schizophrenia

AIM:To compare the effects and the factors between risperidone and chlorpromazine on schizophrenia. METHODS:Fifty five patients with schizophrenia were treated by risperidone with enough dosage and fifty two patients as control by chlorpromazine for 8 wk.The effects of these two drugs were rated with PANSS(Positive and Negative Symptom Scale).All the data were analyzed by the χ 2 , t test and the multiple regression analysis. RESULTS: The total effect of risperidone group and chlorpromazine group was 76 % and 88 %, respectively.The effects of these two groups on positive and general symptoms were better than those on negative ones.The effects of risperidone group were related to the dose,the family history and the severity of symptoms,but those of chlorpromazine group not. CONCLUSION: The effects of risperidone are equal to those of chlorpromazine,but the factors for risperidone differ from those for chlorpromazine.