比较Lorcainide和几种抗心律失常药对实验性心律失常的作用

用麻醉大白鼠和豚鼠研究lorcainide抗心律失常作用,并与普鲁卡因胺、异搏定、苯妥英钠和阿托品进行比较。Iv lorcainide 3 mg/kg可对抗肾上腺素、乌头碱、氯化钡和哇巴因心律失常,但不能对抗氯化钙心律失常。Iv阿托品0.1 mg/kg对抗肾上腺素引起的大鼠心律失常作用强于lorcainide。苯妥英钠iv 20 mg/kg对抗乌头碱引起心律失常的作用比qorcainide显著;iv异搏定1.25 mg/kg对抗氯化钡心律失常的作用超过loreainide。Iv lorcainide 3 mg/kg提高哇巴因引起豚鼠心律失常所需剂量显著超过异搏定,普鲁卡因胺与苯妥英钠。

EFFECT OF LORCAINIDE ON EXPERIMENTAL ARRHYTHMIAS IN COMPARISON WITH OTHER ANTIARRHYTHMIC AGENTS

The antiarrhythmic action of lorcainide was studied on anesthesized rats and guinea pigs and compared with procainamide, verapamil, phenytoin and atropine. Intravenous bolus injection of lorcainide 3 mg/kg was shown to inhibit the cardiac arrhythmias induced by adrenaline, aconitine, BaCl₂ and ouabain, but not CaCl₂. The suppressive action of ⅳ atropine 0.1 mg/kg on adrenaline-induced rat arrhythmia was more potent than that of lorcainide. The suppressive effect of phenytoin (20 mg/kg ⅳ) on aconitine-induced arrhythmias was more significant than that of lorcainide. The effect of iv verapamil 1.25 mg/kg against BaCl₂-indueed arrhythmias was more potent than that of lorcainide; Lorcainide ⅳ 3 mg/kg inhibited ouabain-induced arrhythmias in guinea pigs. The dose required for ouabain to cause arrhythmias in lorcainide-group was more than that of verapamil, procainamide and phenytoin. Lorcainide 2.5×10^-6M also prolonged the functional refractory period of isolated cat left atria.