胃肠道间质瘤中p16、p27、Ki-67表达

目的探讨胃肠道间质瘤中p16、p27和Ki67表达与临床预后的关系。方法根据核分裂象的多少、肿瘤体积的大小及有无浸润等将胃肠道间质瘤划分为良性、交界性和恶性,并运用免疫组化SP方法检测p16、p27和Ki67在胃肠道间质瘤中的表达,并统计分析其良性、交界性、恶性和复发死亡病例中的表达差异。结果p16、p27和Ki67的阳性表达率分别为48%、26%和24%。p16在良、恶性中的表达无明显差异,但在良性和交界性中的表达与复发和转移相关;p27低标记指数和Ki67高标记指数与复发和转移相关。结论p16、p27和Ki67在胃肠道间质瘤中的表达对判断预后有价值。

Clinicopathologic study of the expression of p16, p27 and Ki-67 in gastrointestinal stromal tumors

Purpose To investigate the correlation between clinical prognosis and expression of p16, p27 and Ki-67 in gastrointestinal stromal tumors(GISTs). Methods The cases were grouped into benign, borderline and malignance according to the size, mitosis aggression and metastases by microscopy. p16, p27 and Ki-67 were examined in every group by immunohistochemical method and the difference among those groups was statisticed and analyzed respectively. Results p16 protein, p27 labeling index(p27 LI) and Ki-67 labeling index(Ki-67 LI) were showed 48%,26% and 24% positive in respective. The expression of p16 protein was no different among benign , borderline ,or maligant GISTs. While there was a high predictive value in the lower expression of p16 protein in groups of benign and borderline cases. Furthermore, Low p27 LI and high Ki-67 LI was related to a aggressive behavior. Conclusions The evalution of expression of p16, p27 and Ki-67 in GISTs is helpful in prognoses.