血清与前列腺按摩液CuZn-SOD和MDA检测的临床价值

目的 探讨血清和前列腺按摩液（EPS）中铜锌超氧化物歧化酶（CuZn-SOD）活力、丙二醛（MDA）含量测定对慢性骨盆疼痛综合征（CPPS）病人诊断的价值.方法 将40例CPPS病人和20例健康男性分别采用黄嘌呤氧化酶法测定CuZn-SOD活力,硫代巴比妥酸（TBA）法测定MDA含量.结果 各组血清中CuZn-SOD活力比较差异无显著性（P〉0.05）.炎性组及非炎性组血清中MDA含量明显高于对照组（F=25.70,q=8.21、9.26,P〈0.01）,炎性组与非炎性组间比较差异无显著性（P〉0.05）.炎性组EPS中CuZn-SOD活力明显低于非炎性组及对照组（F=34.78,q=9.30、10.93,P〈0.01）;非炎性组与对照组间比较差异无显著性（P〉0.05）.炎性组EPS中MDA含量明显高于非炎性组及对照组（F=441.63,q=35.73、37.03,P〈0.01）;非炎性组与对照组之间比较差异无显著性（P〉0.05）.结论 血清及EPS中CuZn-SOD、MDA水平可作为CPPS诊断和判断疗效的有意义的辅助指标,SOD制剂在CPPS的治疗中可能具有重要作用.

The clinical significance of serum and EPS CuZn-SOD and MDA detection in patients with chronic pelvic pain syndrome

Objective To determine the levels of CuZn - SOD and MDA in serum and EPS in patients with chronic pelvic pain syndrome （CPPS） and explore their significance in the diagnosis and treatment of this condition. Methods Forty outpatients confirmed as having CPPS were divided into inflammatory group and non - inflammatory group and 20 healthy served as the control. Xanthine Oxidase method was applied to determine the content of CuZn - SOD and TBA method to determine the level of MDA. Results The levels of CuZn - SOD in serum among the three groups were not significantly different （P 〉 0.05）. The serum levels of MDA in CPPS patients were signiticantly higher than that of the control （ F = 25.70; q = 8.21,9.26 ; P 〈 0.01 ）, but no significant difference was noted between the inflammatory and non - inflammatory group （P 〉 0.05）. The vigour of CuZn - SOD in the EPS of the inflammatory group was markedly lower than that in the non - irrflammatory group and the control （ F = 34.78 ; q = 9.30,10.93 ; P 〈 0.01 ）, but no significant difference was noted between the non - inflammatory group and the control （P 〉 0.05）. The MDA in EPS of the inflammatory group was dramatically higher than that in the non - inflammatory and the control （F=441.63;q= 35.73,37.03;P〈0.01）, but no significant difference between the non- inflammatory and the control （P〉 0.05）. Conclusion The oxidative stress of EPS patients with inflammatory CPPS is stronger than that of the healthy adults, while there is no signitlcant diffe - rence of the oxidative stress between patients with the non - inflammatory CPPS and the health young man. Measurements of the levels of CuZn - SOD and MDA, both in serum and El＇S, can serve as valuable parameters in the diagnosis and assessment of the therapy of CPPS.