沙棘总黄酮（TFH）改善血管性痴呆血脂的实验研究

目的探讨沙棘总黄酮（TFH）对＂血管性痴呆＂（VD）血脂的改善作用。方法①采用＂高脂血症血管性痴呆大鼠模型＂进行造模。②造模后和干预后,分别测血脂（TC,TG）,血清脂蛋白（HDL-C和LDL-C）;载脂蛋白A（apoAⅠ）、载脂蛋白B（apoB）。结果①实验组（TFH低、中、高剂量组）干预后与造模后血脂（TC、TG、HDL-C、LDL-C、apoAⅠ、apoB）相比,有统计学意义（P〈0.05）;对照组（丹参注射液）干预后与造模后相比,有统计学意义（P〈0.05）;空白组干预后与造模后相比,无统计学意义（P〉0.05）;②空白组与实验组（低、中、高剂量组）、对照组相比,无统计学意义（P〉0.05）。结论 TFH能明显降低高脂血症型VD模型大鼠的TC、TG、LDL-C、apoAⅠ、apoB,并提高HDL-C。

EXPERIMENTAL STUDY ON THE TOTAL FLAVONES OF HIPPOPHAE (TFH) IN IMPROVING THE BLOOD-LIPID OF PATIENTS WITH VASCULAR DEMENTIA

Objective To use of Total Flavones of Hippophae（TFH） improving vascular dementia by means of intervention of the blood lipid level.Methods ① Established Hyperlipidemic rat model for vascular dementia.②After modeling and intervention,blood lipids were measured（TC、TG,HDL-C and LDL-C,apoAⅠ、apoB） and compared with the control group.Results ①Experimental group（low,medium and high dose of TFH group） were intervened with TFH and detected the blood lipid（TC,TG,HDL-C,LDL-C,apoAⅠ,apoB）,then compared them to control group.It showed a statistically significant（P 0.05） data compared with the control group（Danshen injection）;there was no statistical significance（P 0.05） between placebo with intervention group and model group.② There were no statistical significance（P 0.05） among Placebo group,experimental group（low,medium and high dose of TFH group）and the control group.Conclusion TFH is significantly reduced hyperlipidemia including VD,TC,TG,LDL-C,apoAⅠand apoB and increased HDL-C in rats.