8659例孕中期母血清产前筛查结果分析

目的 通过对近3年佛山市禅城区中心医院孕中期母血清筛查结果进行回顾性分析,了解佛山地区产前筛查出生缺陷检出情况,为减少出生缺陷、提高生育质量提供依据.方法 采用时间分辨荧光法测定母血清三联标志物（AFP、Free β-hCG、uE3）,通过产前筛查专用计算软件2T-Risks进行分析计算,并建议对高风险人群进行B超检查及羊水穿刺分析.结果 筛查8659例对象中发现高风险孕妇639例,发生率为7.38%,其中唐氏综合征（Down,s syndrome,DS）高风险81例,爱德华兹综合征（18-三体综合征）高风险22例,神经管畸形（NTD）高风险79例,年龄高风险457例,确诊唐氏综合征（DS）8例,爱德华兹综合征（18-三体综合征）3例,神经管畸形（NTD）7例,死胎1例,其他胎儿畸形3例.对低风险人群进行随访,未发现有胎儿出现畸形等出生缺陷情况,未出现假阴性.结论 孕中期母血清产前筛查可明显减少胎儿出生缺陷,孕中期母血清产前筛查结合B 超及羊水穿刺检查可提高出生缺陷的检出率,可作为减少出生缺陷的重要手段.

The analysis of 8659 case second trimester maternal serum screening results

OBjective In order to reduce birth defects and improve the quality of natality, the second trimester maternal serum screerting results were analyzed to comprehend the detection of prenatal screening for birth defects in Foshan area in the past 3 years, at Chaneheng Central Hospital of Foshan. Methods The time - resolved fluorescence method were used for the determination maternal serum triple - markers （AFP, Free β - hCG, uE3）, and the analysis or the calculation were conducted by special computing software 2T- Risks. According to the results of detection, the high - risk groups were recommended for B - ultrasound and amnioeentesis analysis. Results There were 639 cases of high - risk pregnant in the screening of 8659 women, the rate reached 7.38 %, including 81 cases of high - risk of Down syndrome （ Down, s syndrome, DS）, 22 eases of high - risk of Edwards syndrome （trisomy 18 syndrome ）, 79 cases of high - risk of neural tube defects （ NTD）, 457 cases of high - risk age. At last, the results of diagnosed showed there were 8 cases of Down syndrome （DS）, 3 cases of Edwards syndrome （trisomy 18 syndrome）, 7 cases of nerve tube defects （NTD）, 1 case of fetal death, and 3 cases of fetal malformation. We never found fetal deformity and other birth defects eases in low - risk populations. Conclusions we found it can significantly reduce fetal birth defects by prenatal second trimester maternal serum screening, if amniotic fluid puncture and B - examination were conducted at the same time, the detection rate of birth defects can be improved further.