| FAS-1377基因多态与胃癌TNM分期的关系 |
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| 引用本文： | 胡英,金丽艳,耿排力. FAS-1377基因多态与胃癌TNM分期的关系[J]. 青海医学院学报, 2010, 31(4): 239-241 |
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| 作者姓名： | 胡英 金丽艳 耿排力 |
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| 作者单位： | 1. 青海大学医学院基础医学部
2. 青海大学附属医院 |
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| 基金项目： | 青海大学中青年科研基金 |
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| 摘 要： | 目的研究FAS-1377基因多态与胃癌TNM分期的关系。方法采用聚合酶链反应-限制性片段长度多态性（PCR—RFLP）分析方法，检测120例胃癌患者的FAS-1377基因多态性，用PearsonX。检验法分析其基因多态性与胃癌TNM分期的关系。结果FAS-1377基因多态频率分布：纯合野生型GG为7．4％（7／95）、杂合型GA为61．1％（58／95）、纯合突变型AA为31．5％（30／95）。胃癌患者FAS-1377基因型与TNM分期无统计学意义（P=0．274）。结论FAS-1377基因多态与青海地区胃癌患者TNM分期无相关性。
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| 关 键 词： | 胃癌 凋亡基因 基因多态性 分期 |
THE ASSOCIATION BETWEEN FAS-1377 POLYMORPHISMS AND TNM STAGING OF GASTRIC CANCER |
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| Hu Ying,Jin liyan,Geng Paili. THE ASSOCIATION BETWEEN FAS-1377 POLYMORPHISMS AND TNM STAGING OF GASTRIC CANCER[J]. Journal of Qinghai Medical College, 2010, 31(4): 239-241 |
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| Authors: | Hu Ying Jin liyan Geng Paili |
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| Affiliation: | 1. Qinghai University Medical college, 2. Qinghai University Affiliated Hospital) |
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| Abstract: | Objective To investigate the correlation between FAS polymorphisms and TNM staging of gastric cancer. Methods The polymorphisms of FAS were detected by polymerase chain reaction - restriction fragment length polymorphisms assay （PCR -RFLP） in 120 gastric cancer patients ,Pearson X2 was applied to assess the association between the polymorphisms of FAS and TNM staging of gastric cancer. Results The frequency of FAS - 1377 gene polymorphism is that homozygous wild -type GG is 7.4 percent （7/95）, heterozygous GA is 61.1 percent（58/95） and homozygous mutant AA is 31.5 percent（30/95）. FAS- 1377 gene polymorphism of gastric cancer patients was not associated with clinical stage, （P = 0. 274）. Conclusions FAS - 1377 may not be associated with TNM staging of gastric cancer. |
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| Keywords: | Gastric cancer Apoptotic gene Gene polymorphisms Stage |
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