| 糙海参多糖纯化工艺优选及其产物的药理活性比较 |
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| 引用本文： | 沈鸣,陈建伟. 糙海参多糖纯化工艺优选及其产物的药理活性比较[J]. 中国海洋药物, 2003, 22(1): 1-4 |
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| 作者姓名： | 沈鸣 陈建伟 |
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| 作者单位： | 南京中医药大学,江苏,南京,210029 |
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| 基金项目： | 江苏省科技兴海资助项目 (项目编号 :BL9712 0 ) |
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| 摘 要： | 通过正交实验发现糙海参多糖粘度和脱色时的温度，时间，多糖浓度和H2O2浓度有关。温度升高，时间延长，多糖浓度减小和H2O2浓度增大使产物粘度减小，并且不同粘度的糙海参多糖对小鼠急性脑缺血死亡时间的影响不同，在一定的范围内，随粘度减小，死亡时间延长，因此在生产中对多糖生产工艺的控制至关重要。
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| 关 键 词： | 糙海参多糖 工艺优选 产物 药理 活性 |
| 文章编号： | 1002-3461(2003)01-0001-04 |
| 修稿时间： | 2002-05-29 |
Purification Technology of Mucopolysaccharides in Holothuria scabra Jaeger and Pharmacologic Activity of the Products |
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| SHEN Ming,CHEN Jian wei. Purification Technology of Mucopolysaccharides in Holothuria scabra Jaeger and Pharmacologic Activity of the Products[J]. Chinese Journal of Marine Drugs, 2003, 22(1): 1-4 |
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| Authors: | SHEN Ming CHEN Jian wei |
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| Abstract: | The viscosity of mucopolysaccharides in Holothuria scabra Jaeger was related to temperature, time, concentration of mucopolysaccharides and H 2O 2 during the decoloration, which was found through the experiment, in that the rise of temperature, elongation of time, decrease of concentration of Mucopolysaccharides and increase of that of H 2O 2 all lead to the decrease of the viscosity. Within a certain limit, the activity of mucopolysaccharides rises with the viscosity decrease in the experiment of acute cerebral ischemia in mice. So that it is important controlling the craft in the mucopolysaccharides production. |
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| Keywords: | Mucopolysaccharides in Holothuria scabra Jaeger purification technology orthogonal design pharmacologic activity |
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