| 肥大细胞与肿瘤血管生成 |
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| 引用本文： | 曹莉,李维,邓凡. 肥大细胞与肿瘤血管生成[J]. 国际肿瘤学杂志, 2013, 40(7): 483-485 |
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| 作者姓名： | 曹莉 李维 邓凡 |
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| 作者单位： | 南方医科大学细胞生物学教研室, 广州,510515 |
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| 摘 要： | 肥大细胞(MC)是起源于骨髓,定居于组织的免疫细胞.肿瘤可以通过干细胞因子(SCF)及其在肥大细胞上的受体c-kit来介导对MC的募集.MC在肿瘤部位的数量和分布与肿瘤的生长、血管新生密切相关.MC可以通过释放血管生成因子介导血管新生,促进肿瘤的进展.
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| 关 键 词： | 肥大细胞 肿瘤 新生血管化,病理性 |
Mast cells and tumor angiogenesis |
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| CAO Li , LI Wei , DENG Fan. Mast cells and tumor angiogenesis[J]. Journal of International Oncology, 2013, 40(7): 483-485 |
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| Authors: | CAO Li LI Wei DENG Fan |
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| Affiliation: | Department of Cell Biology, Southern Medical University, Guangzhou 510515, China |
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| Abstract: | Mast cells (MCs) are bone marrow-derived and tissue-homing immune cells which have important functions. Recruitment and activation in tumors are demonstrated to be mainly mediated by tumor-derived stem cell fact MCs in tumors are closely related to the growth of tumors and angiogenesis. MCs can or (SCF) and its receptor c-kit on MCs. Neovascularization is necessary for the tumor growth by providing plenty of nutrients and oxygen. The numbers and distributions of mediate angiogenesis by releasing a series of angiogenesis factors, so as to promote the progress of tumors. |
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| Keywords: | Mast cells Neoplasms Neovascularization,pathologic |
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