| Relationship between estrogen receptor gene polymorphism and clinical indexes as-sociated with coronary heart disease ＊ |
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| 引用本文： | 吴赛珠,李曦,郑华,郭志刚,赖文岩,吴迎星,Wei Heming.Relationship between estrogen receptor gene polymorphism and clinical indexes as-sociated with coronary heart disease ＊[J].中国人民解放军军医大学学报,2003,18(4):255-257,266. |
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| 作者姓名： | 吴赛珠 李曦 郑华 郭志刚 赖文岩 吴迎星 Wei Heming |
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| 作者单位： | Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China,Department of Basic Medical Sciences,First Military Medical University,Guangzhou 510515,China,Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China,Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China,Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China,Department of Cardiology,Nanfang Hospital,First Military Medical University,Guangzhou 510515,China |
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| 基金项目： | Supported by the Key Basic Research and Development Project of National "973" Program of China (G200057008),the Foundation for University Leading Teachers Sponsored by the Ministry of Education of China, and by Funds for Key Natural Science Research of |
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| 摘 要： | Objective: To investigate the relationship between estrogen receptor (ER) gene and the clinical indexes associated with coronary heart disease ( CHD). Methods: By means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) , we analyzed ER gene polymorphism in 84 CHD patients and 61 healthy subjects and non-CHD inpatients. The clinical indexes associated with CHD were analyzed in relation to the three ER genotypes. Results: There were significant differences in the incidence of hypertension (58.62% ), fibrinogen (Fib) concentration (3. 5±0. 8 g/L) , body mass index (BMI, 25. 1±3. 2) , HDL-C concentration (1.0±0. 2 mmol/L) between PP genotype group and other genotype groups (P <0. 05). Conclusion: ER gene polymorphism may affect ER-mediated cardiovascular protective effect by modulating the expression of ER.
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| 关 键 词： | 雌激素受体 基因多态性 冠心病 PCR-RFLP法 |
Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease |
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| Wei Heming.Relationship between estrogen receptor gene polymorphism and clinical indexes associated with coronary heart disease[J].Journal of Medical Colleges of PLA(China),2003,18(4):255-257,266. |
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| Authors: | Wei Heming |
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| Abstract: | Objective: To investigate the relationship between estrogen receptor(ER) gene and the clinical indexes associated with coronary heart disease (CHD). Methods: By means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), we analyzed ER gene polymorphism in 84 CHD patients and 61 healthy subjects and non-CHD inpatients. The clinical indexes associated with CHD were analyzed in relation to the three ER genotypes. Results: There were significant differences in the incidence of hypertension (58.62%), fibrinogen (Fib) concentration (3.5±0.8 g/L), body mass index (BMI, 25.1±3.2), HDL-C concentration (1.0±0.2 mmol/L) between PP genotype group and other genotype groups (P<0.05). Conclusion: ER gene polymorphism may affect ER-mediated cardiovascular protective effect by modulating the expression of ER. |
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| Keywords: | estrogen receptor gene polymorphism coronary heart disease |
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