| 仙茅苷对自由基的清除作用 |
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| 引用本文： | 吴琼a,程小卫a,雷光青a,陈士明b,陈家宽a,周铜水a. 仙茅苷对自由基的清除作用[J]. 中国现代应用药学, 2007, 24(1): 6-9 |
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| 作者姓名： | 吴琼a 程小卫a 雷光青a 陈士明b 陈家宽a 周铜水a |
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| 作者单位： | 1. 复旦大学生命科学学院天然药物研究中心,上海,200433
2. 复旦大学分析测试中心,上海,200433 |
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| 摘 要： | 目的研究仙茅(Curculigo orchioidesGaertn.)主要成分仙茅苷(curcu ligoside)对羟自由基和超氧阴离子自由基的清除作用。方法分别采用比色法及电子顺磁共振技术(ESR)测定仙茅苷对羟自由基和超氧阴离子自由基的清除效果。结果仙茅苷对羟自由基和超氧阴离子自由基均有良好的清除作用,其清除率略低于茶多酚。结论仙茅苷对自由基具有明显的清除作用,是一种有效的天然抗氧化剂。
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| 关 键 词： | 仙茅 仙茅苷 羟自由基 超氧阴离子自由基 清除作用 |
| 文章编号： | 1007-7693（2007）01-0006-04 |
| 修稿时间： | 2006-04-20 |
Effect of Curculigoside on Free Radical Scavenging |
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| WU Qiong,CHENG Xiao-wei,LEI Guang-qing,CHEN Shi-ming,CHEN Jia-kuan,ZHOU Tong-shuia. Effect of Curculigoside on Free Radical Scavenging[J]. The Chinese Journal of Modern Applied Pharmacy, 2007, 24(1): 6-9 |
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| Authors: | WU Qiong CHENG Xiao-wei LEI Guang-qing CHEN Shi-ming CHEN Jia-kuan ZHOU Tong-shuia |
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| Affiliation: | a. Research Center of Natural Medicine, School of Life Sciences; b. Research Center of Analysis and Measurement, Fudan University, Shanghai 200433, China |
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| Abstract: | OBJECTIVE To study the scavenging effects of curculigoside,a main compound isolated from Curculigo orchioides Gaertn.,on hydroxyl and superoxide anion radicals.METHODS Colorimetric method and electron spine resonance(ESR) technique were applied,respectively,to determine the radical clearance ratio of curculigoside on hydroxyl and superoxide anion radicals. RESULTS As the data showed,curculigoside exhibited effective antioxidant activities on both hydroxyl and superoxide anion radicals,but the radical scavenging ratios were slightly lower than those of(-)-Epigallocatechin gallate(EGCG).CONCLUSION Curculigoside has the capability to scavenge radicals and serves as one of the active natural antioxidants. |
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| Keywords: | Curculigo orchioides curculigoside hydroxyl radicals superoxide anion radicals scavenging activities |
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