Clonal evolution in cutaneous malignant histiocytosis |
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| Authors: | GUNHILD LANGE WANTZIN,ELISABETH RALFKIÆ R,JØ RGEN K. LARSEN&dagger ,KRISTIAN THOMSEN |
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| Affiliation: | Department of Dermatology, The Finsen Institute, Copenhagen, Denmark;Department of Pathology, The Finsen Institute, Copenhagen, Denmark;The Finsen Laboratory, The Finsen Institute, Copenhagen, Denmark |
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| Abstract: | A 56–year-old woman is reported with malignant histiocytosis which for 17 months was confined to the skin but eventually involved lymph nodes, blood and bone marrow. Using DN'A measurements by flow cytometry a clonal evolution from an abnormal hyperdiploid to a hypotetraploid cell clone took place when the patient went from the cutaneous to the disseminated phase of the disease. Thus DNA measurements upon tumours may predict the transition from the cutaneous to the disseminated stage. |
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