Diversity and evolution of the DRB1*03 family: description of DRB1*03022, *0307, **0308 |
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| Authors: | J. M. Ellis N. Steiner J. Wang T. T. Tang C. K. Hurley |
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| Affiliation: | Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, District of Columbia;Naval Medical Research Institute, Bethesda, Maryland;Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA |
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| Abstract: | Three previously unreported DRB1*03 alleles are described, adding to the diversity of the DRB 1 family of alleles. DRB1*03022 contains a silent substitution at codon 77. DRB1*0307 differs from DRB1*03011 by a substitution at codon 26 resulting in a predicted change from tyrosine to phenylalanine. DRB1*0308 is almost identical to DRB1*03011 differing at codon 58 which specifies the glutamic acid residue commonly found in DRB1*11 alleles. The new alleles (DRB1*03022, *0307, *0308) may have arisen by gene conversion-like events and add to the increasing complexity of the HLA system. |
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| Keywords: | DR3 evolution gene conversion human leukocyte antigen (HLA) |
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