兰索拉唑和雷尼替丁治疗胃溃疡疗效对比研究

目的：对兰索拉唑和雷尼替丁治疗胃溃疡病近期和远期愈合率进行对比研究。方法：６１例经内镜证实的活动性胃溃疡病，随机分成兰索拉唑组和雷尼替丁组，先行６周治疗，兰索拉唑每日３０ｍｇ，雷尼替丁１５０ｍｇ，每日二次，对愈合的５０例进行１年期治疗，兰索拉唑每３天３０ｍｇ，雷尼替丁每天１５０ｍｇ。结果：兰索拉唑和雷尼替丁组６周溃疡愈合率分别为９３．５％（２９／３１例）和７０％（２１／３０例），１年愈合率分别为９

Contrastive Study of Effect of Lansoprazole and Ranitidine On Treatment in Gastric Ulcer Disease

ObjectiveTo Study the Effect of Lansoprazole in contrast with ranitidine on healing rate in the short-term and in the long-term in gastric ulcer disease. Methods sixty-one patients with endoscopicall proven active gastric ulcer disease were randomly allocated to treatment with lansoprazole and ranitidine respectively. Lansoprazole was used in a dose of 30mg P.O. daily and ranitidine 150mg P.O. twice a day for 6 weeks. After ulcer healing, Patients (50 to date) were treated with lansoprazole (30mg P.O. for three days) and ranitidine (150mg/day P.O.) for one year long-term maintenance therapy. Results At the end of the short-term (6 weeks) treatment 93.5% (29/31) of ulcers were healed with lansoprazole vs 70% (21/30) with ranitidine. At the end of the Long-term (1 year) treatment 93.1% (27/29) of ulcers were healed with lansoprazole vs 71.4%(15/21) with ranitidine. Conclusion The treatment gastric ulcer healing rate in the short-term and in the long-term is higher with lansoprazole than ranitidine.