大肠息肉与大肠癌的演变关系（附494例分析）

本组息肉患者４９４例，癌变者１０１例，随着息肉的增大，其癌变率也增加。恶变息肉主要分布在直肠（５７．４％），次为乙状结肠（１９．８％）。管状腺瘤瘤体较小，恶变率较低，绒毛型腺瘤瘤体较大，恶变率较高，且呈重度不典型增生多见。单发息肉癌变率１３．１％，２－５个息肉者癌变率２４．４％，６个以上者癌变率３８．０％，腺瘤病１２例全部癌变。息肉癌变时间１至１５年。癌变术后标本病理均见癌旁组织残存良性管状腺瘤或绒毛型腺瘤成份，从组织学上证明了息肉癌变过程。

THE RELATIONSHIP BETWEEN POLYP AND CARCINOMA OF LARGE INTESTINE

There were 101 cases malignant changes among 494 polyps cases.As the polyps enlarged in size;the malignant change increased. Malignant polyps were mainly distributed in rectum(57. 4%),then sigmoid (19. 80%). The smaller the size of tubular adenoma,the lower the incidence of malignant change;the larger the size of villous adenoma, the higher incidence of malignant change,and were accompanied with severe dysplasia. Malignant changes were 13.1% in single polyp, 24. 4% in 2-5polyps, and 38. 0% in more than 6 polyps, malignant changes occured all in 12 cases of polyposis. In this group,time of malignant change of polyps varied from 1 to 15 years. Benign tubular adenoma or villous adenoma remained in postoperative specimen surrounding 101 cancer cases. Histologically it proved the developing process from polyp to cancer.