Evaluation of plexiform neurofibroma in neurofibromatosis type 1 in 18 family members of 3 generations: ultrasonography and magnetic resonance imaging a diagnostic supplement |
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| Authors: | Virendra N Sehgal MD FNASC FAMS FRAS Sonal Sharma MD Rakesh Oberai MD |
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| Institution: | From the Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Delhi, University College of Medical Sciences and Associated GTB Hospital, Delhi, and Ganash Diagnostic and Imaging Centre, Rohini, New Delhi, India |
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| Abstract: | Plexiform neurofibroma in neurofibromatosis type 1, an autosomal-dominant genetic disorder, is characterized by a combination of interlacing components or a network. The prominent enlargement of a nerve with tumor nodules results in the gross pathologic appearance termed "bag of worms." Plexiform neurofibroma was found in two of seven family members with neurofibromatosis type 1 in three generations. Ultrasonography/color doppler and magnetic resonance imaging, in addition to microscopic pathology, were used as diagnostic tools, and their indications for future use in the diagnosis of plexiform neurofibroma are highlighted. |
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