| 一氧化碳保护机制的研究进展 |
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| 引用本文： | 马可,徐鑫荣,胡祖鹏. 一氧化碳保护机制的研究进展[J]. 中国病理生理杂志, 2008, 24(9): 1865-1868. DOI: 1000-4718 |
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| 作者姓名： | 马可 徐鑫荣 胡祖鹏 |
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| 作者单位： | 1复旦大学附属华山医院急诊科， 上海 200014; 2南京医科大学第一附属医院ICU， 江苏 南京 210029 |
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| 摘 要： | 多年来,一氧化碳(carbon monoxide,CO)被认为是一种可以致命的毒性气体.1968年时,已认识到机体可以产生内源性的CO,血红素氧合酶是内源性CO产生的限速酶.上个世纪九十年代,随着一氧化氮(NO)作为一种气体信使分子的作用被逐渐了解,同为气体小分子的CO,在体内的生理作用也逐渐得到重视,CO成为第二种被发现有病理生理作用的气体信使分子.
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| 关 键 词： | 一氧化碳 血红素氧合酶 抗炎 抗细胞凋亡 白细胞黏附 血小板聚集 |
| 收稿时间： | 2007-10-30 |
| 修稿时间： | 2008-03-24 |
Research progress of carbon monoxide protection mechanism |
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| MA Ke,XU Xin-rong,HU Zu-peng. Research progress of carbon monoxide protection mechanism[J]. Chinese Journal of Pathophysiology, 2008, 24(9): 1865-1868. DOI: 1000-4718 |
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| Authors: | MA Ke XU Xin-rong HU Zu-peng |
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| Affiliation: | 1Emergency Department, Huashan Hospital Affiliated Fudan University, Shanghai 200040, China; 2 ICU, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. E-mail: makege@163.com |
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| Abstract: | Carbon monoxide (CO) has been considered as a fatal gas. Recent researches show that tissues generate carbon monoxide, and carbon monoxide plays a key role in the tissue physiological and pathological processes. The endogenous CO is generated from the decomposition of heme which is catalyzed by heme oxygenase enzyme (HO). Studies show that CO involves in the process of anti-inflammation, anti-apoptosis, regulation of vascular tone, modulation of leukocyte adhesion and platelet aggregation. CO also functions as neurotransmitters. |
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| Keywords: | Carbon monoxide Heme oxygenase Anti-inflammation Anti-apoptosis Leukocyte adhesion Platelet aggregation Neurotransmitters |
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