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DNA-synthesizing T and non-T cells in chronic lymphocytic leukemia |
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| Authors: | van der Woerd-de Lange J A Döhrmann J Huber Ch Schick P Kauert K Begemann H |
| Institution: | (1) StÄdtisches Krankenhaus Schwabing, I. Medizinische Abteilung, Kölner Platz l, D-8000 München 40, Germany;(2) Medizinische UniversitÄtsklinik, A-6020 Innsbruck, Austria;(3) Abt. Klinische Morphologie der UniversitÄt, D-7900 Ulm, Germany |
| Abstract: | Summary In 21 patients with chronic lymphocytic leukemia (CLL) and in 8 hematologically normal persons the number of DNA-synthesizing peripheral blood lymphocytes was investigated by autoradiographic techniques. The lymphocytes were differentiated by En-rosette tests into T and non-T lymphoid cells. The results show a normal number of proliferating T lymphoid cells and an increased number of proliferating non-T lymphoid cells in clinical stages O-I. Stages III–IV demonstrate a significant increase of the proliferation rate of both T and non-T lymphoid cells. The possible pathogenetic factors and the prognostic value of these results are discussed.This work was supported by the Deutsche Forschungsgemeinschaft (Be 79/15) and by the Austrian Funds  Zur Förderung der wissenschaftlichen Forschung and Kampf dem Krebs |
| Keywords: | Chronic lymphocytic leukemia T lymphocytes Lymphoid S-phase cells DNA-synthesizing cells S-phase T lymphoid cells |
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