| 新基因mcpr1在小鼠牙胚发育中的时空表达和意义 |
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| 引用本文： | 轩东英,金岩,金明,轩昆,邢向辉,郑梁,赵征. 新基因mcpr1在小鼠牙胚发育中的时空表达和意义[J]. 实用口腔医学杂志, 2005, 21(6): 730-732 |
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| 作者姓名： | 轩东英 金岩 金明 轩昆 邢向辉 郑梁 赵征 |
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| 作者单位： | 1. 西安第四军医大学口腔医学院组织病理教研室,第四军医大学组织工程中心,710032
2. 西安第四军医大学基础部生化教研室 |
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| 摘 要： | 目的:探讨mcpr1在牙胚发生过程中的可能作用。方法:采用免疫组化LsAB法观察MCPR1在小鼠牙胚发育各个时期的表达分布及其变化情况。结果:MCPR1在小鼠牙胚各个时期均有表达,但各期分布模式有所不同,帽状期开始在成釉器上皮细胞表达,在釉结节内亦呈现强阳性表达,在分化成熟的成牙本质细胞及成釉细胞内呈现出强阳性表达。结论:mcpr1可能通过上皮-间充质之间的信号传递及相关基因的相互调控,参与成釉器的成熟及牙胚的发育。
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| 关 键 词： | mcpr1 牙胚发育 免疫组织化学 |
| 文章编号： | 1001-3733(2005)-06-0730-03 |
| 收稿时间： | 2005-03-02 |
| 修稿时间： | 2005-08-15 |
The expression and function of mcpr1 gene during mouse tooth germ development |
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| Xuan Dongying,Jin Yan,Jin Ming. The expression and function of mcpr1 gene during mouse tooth germ development[J]. Journal of Practical Stomatology, 2005, 21(6): 730-732 |
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| Authors: | Xuan Dongying Jin Yan Jin Ming |
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| Abstract: | Objective:To observe the temporal and spatial expression and function of mcpr1 gene during murine tooth germ development.Methods:The expression of MCPR1 at different stages of mouse tooth germ were detected by immunohistochemical staining.Results:MCPR1 expression was detected at all stages of tooth germ, but the distribution patterns at various stages were different. It indicated that the temporal and spatial expression pattern of MCPR1 during murine tooth germ development was specific.Conclusion:mcpr1 might play an important role in modulating the differentiation and mature of enamel organ. |
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| Keywords: | Mouse cleft palate related gene Tooth germ development Immunohistrochemistry |
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