白术生、制品对脾虚大鼠血清SS,GAS,CHE的影响

目的:研究白术生品及麸炒品对利血平所致脾虚模型大鼠生长抑素(SS)、胃泌素(GAS)、胆碱酯酶(CHE)的影响.方法:将大鼠平均分成5组,即空白对照组,白术生品组,白术麸炒品组,阳性药莫沙必利组,模型组,每组10只,利血平0.5 mg·kg-1 sc 7 d复制大鼠脾虚模型.造模成功后,莫沙必利溶液按7 mL·kg-1(0.7 mg·kg-1)ig7 d,白术生品、麸炒品水煎液20 g·kg-1 ig 7 d后取血清,测定大鼠血清中SS,GAS含量,CHE活力.结果:与正常组比较模型组大鼠血清中SS,GAS含量显著降低,CHE活力显著升高(P＜0.05)；白术生品及麸炒组大鼠血清中CHE活力较模型组显著降低；SS,GAS含量与模型组相比有升高的趋势,总体麸炒白术作用优于生品.结论:白术生品及白术麸炒品对利血平所致大鼠脾虚模型有较好的治疗作用.

Influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma Fried with Bran on SS, GAS, CHE of in Rat Spleen Deficiency Model

Objective: To study the influence of Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma fried with bran on somatostatin (SS), gastrin (GAS), cholinesterase (CHE)in rat spleen deficiency model. Method: The rats were divided into five groups, namely blank group, Atractylodis Macrocephalae Rhizoma raw group, Atractylodis Macrocephalae Rhizoma fried with bran group, positive drug group, model group, 10 rats each group. Subcutaneous injection of reserpine was used to make rat spleen deficiency model, after modeling, the serum was separated, CHE activity, SS and GAS content were assayed. Result: In the model group, the content of SS,GAS in the serum was significantly reduced,CHE activity increased. The crude Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma with bran fried could decrease CHE activity;SS, GAS content increased compared with the model group. Conclusion: The raw Atractylodis Macrocephalae Rhizoma and Atractylodis Macrocephalae Rhizoma fried with bran have a better therapeutic effect.