| 头孢西丁钠在葡萄糖氯化钠钾注射液中的稳定性考察 |
| |
| 引用本文： | 翁小红,储蓉.头孢西丁钠在葡萄糖氯化钠钾注射液中的稳定性考察[J].抗感染药学,2010,7(2):113-114. |
| |
| 作者姓名： | 翁小红 储蓉 |
| |
| 作者单位： | 1. 苏州市立医院,药剂科,江苏,苏州,215002
2. 苏州药品检验所,江苏,苏州,215002 |
| |
| 摘 要： | 目的:考察室温(25℃)下注射用头孢西丁钠在葡萄糖氯化钠钾注射液中的稳定性。方法:采用高效液相色谱法测定配伍液中头孢西丁钠的质量浓度,并考察配伍液外观、pH值及不溶性微粒的变化。结果:头孢西丁钠与葡萄糖氯化钠钾注射液配伍后8h内其外观、pH值及质量浓度均无明显变化,不溶性微粒符合药典规定。结论:注射用头孢西丁钠室温(25℃)下可与葡萄糖氯化钠钾注射液配伍,8h内使用。
|
| 关 键 词： | 头孢西丁钠 葡萄糖 氯化钠 氯化钾 配伍稳定性 高效液相色谱法 |
Stability of Cefoxitin Sodium for Injection Mixed with Glucose and Sodium Chloride Potassium Chloride Injection |
| |
| WENG Xiao-hong,CHU Rong.Stability of Cefoxitin Sodium for Injection Mixed with Glucose and Sodium Chloride Potassium Chloride Injection[J].Anti-infection Pharmacy,2010,7(2):113-114. |
| |
| Authors: | WENG Xiao-hong CHU Rong |
| |
| Institution: | 1 Municipal Hospital of Suzhou,Suzhou Jiangsu 215002,China;2Suzhou Institute for Drug Control,Suzhou Jiangsu 215002,China |
| |
| Abstract: | Objective：To study the stability of cefoxitin sodium for injection mixed with glucose and sodium chloride-potassium chloride injection（GNK） at room temperature（25 ℃）.Methods：The mass concentration of cefoxitin was determined by HPLC,the appearance of the solution was observed and its pH value and particles were tested.Results：There were no significant changes in appearance,pH value and mass concentration of the mixed solution within eight hours,and the particles met the pharmacopoeia requirements.Conclusion：Cefoxitin sodium for injection mixed with GNK at room temperature（25 ℃ ）was compatible and it should be used within 8 hours. |
| |
| Keywords: | Cefoxitin sodium glucose sodium chloride potassium chloride compatible stability HPLC |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
