Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis |
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| Authors: | Ayako Kobori Yuhki Yagi Hirotsugu Imaeda Hiromitsu Ban Shigeki Bamba Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh |
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| Affiliation: | (1) Department of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520-2192, Japan;(2) Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu 520-2192, Japan; |
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| Abstract: | Background Interleukin (IL)-33 is a cytokine belonging to the IL-1 family. IL-33 has been shown to elicit a Th2-like cytokine response in immune cells. In this study, we investigated IL-33 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD), and characterized the molecular mechanisms responsible for IL-33 expression in human colonic subepithelial myofibroblasts (SEMFs). |
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