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| 体外环境下纤溶酶及不同载药量对纤维蛋白胶缓释作用影响 | |
| 引用本文： | 申维喜,杨宇,姜秋颖,黄丽军,张倩,黄大勇,王文秀,齐丽萍,邵蔓丽.体外环境下纤溶酶及不同载药量对纤维蛋白胶缓释作用影响[J].黑龙江医药,2011,24(6):894-897. |
| 作者姓名： | 申维喜 杨宇 姜秋颖 黄丽军 张倩 黄大勇 王文秀 齐丽萍 邵蔓丽 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院肿瘤内科,黑龙江哈尔滨,150086 2. 哈尔滨医科大学附属二院药学部,黑龙江哈尔滨,150086 3. 北京庇利积臣医院门诊部,北京,100027 |
| 基金项目： | 黑龙江省教育厅科研基金 |
| 摘 要： | 目的：考察纤溶酶及不同载药量对顺铂-纤维蛋白胶复合物在体外缓释作用的影响。方法：采用衍生-紫外分光光度法对顺铂-纤维蛋白胶复合物体外释放样本进行测定。观察纤溶酶对不同栽药量纤维蛋白胶（6-bfin出ue，简称FG）的释放过程是否存在影响。结果：溶介为纤溶酶时早期（24h）药物释放相对较快，1h和24h时间点溶液中药物浓度存在差异（P〈0．05）。结论：体外环境下纤溶酶对顺铂-纤维蛋白胶复合物（CDDP／FG）缓释过程早期存在影响。不同栽药量对其缓释作用无影响。 |
| 关 键 词： | 顺铂 纤维蛋白胶 缓释作用 |
Investigation on the Influencing Factors between Plasminogen and Different Drug Loading for Released from Fibrin Glue in Vitro |
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| Institution: | Shen Weixi,et al The Second Affiliated Hospital of Harbin Medical University(150086) |
| Abstract: | Objective：To investigate on the influencing factors between plasminogen and different drug loading for CDDP re- leased from fibrin glue in vitro respectively. Methods：The derivatives - UV spectrophotometry was used to determine the samples of cisplatin - fibrin complex - glue and to observe whether it effected the drug delivery between the plasminogen and different drug loading. Results：For the plasmin -mediated dissolution at an early stage （24h）drug release is relatively fast, l h and 24h time points drug concentrations in solution are different（P 〈0. 05）. Condusion：Plasmin in vitro environment,eisplatin - fibrin glue eomplexes（CDDP / FG） during the early stage of slow- release effect. different drug loading had no effect on their releas. |
| Keywords: | CDDP fibrin glue delivery |
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